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020 |a 9780691220161  |q (electronic bk.) 
020 |a 0691220166  |q (electronic bk.) 
020 |z 0691095949  |q (cl. ;  |q alk. paper) 
020 |z 9780691095943  |q (cl. ;  |q alk. paper) 
020 |z 0691095957  |q (pbk. ;  |q alk. paper) 
020 |z 9780691095950  |q (pbk. ;  |q alk. paper) 
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037 |a 22573/ctv15qsxpv  |b JSTOR 
050 4 |a QR184  |b .F73 2002 
060 4 |a 2002 I-996 
060 4 |a WC 100  |b F828i 2002 
072 7 |a MED  |x 044000  |2 bisacsh 
082 0 4 |a 616.9/0479  |2 21 
049 |a UAMI 
100 1 |a Frank, Steven A.,  |d 1957- 
245 1 0 |a Immunology and evolution of infectious disease /  |c Steven A. Frank. 
260 |a Princeton :  |b Princeton University Press,  |c ©2002. 
300 |a 1 online resource (x, 348 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a Title from electronic title page (viewed August 3, 2007). 
504 |a Includes bibliographical references. 
505 0 |a Vertebrate immunity -- Benefits of antigenic variation -- Molecular processes -- Specificity and cross-reactivity -- Generative mechanisms -- Individual interactions -- Immunodominance within hosts -- Parasite escape within hosts -- Population consequences -- Genetic variability of hosts -- Immunological variability of hosts -- Genetic structure of parasite populations -- Studying evolution -- Classifications by antigenicity and phylogeny -- Experimental evolution: foot-and-mouth disease virus -- Experimental evolution: influenza -- Experimental evolution: CTL escape -- Measuring selection with population samples -- Recap of some interesting problems. 
520 8 |a Annotation  |b From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine. The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense--an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens. This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease. 
590 |a JSTOR  |b Books at JSTOR Demand Driven Acquisitions (DDA) 
590 |a JSTOR  |b Books at JSTOR Evidence Based Acquisitions 
590 |a JSTOR  |b Books at JSTOR All Purchased 
650 0 |a Immunogenetics. 
650 0 |a Host-parasite relationships  |x Genetic aspects. 
650 0 |a Microorganisms  |x Evolution. 
650 0 |a Antigens. 
650 0 |a Molecular evolution. 
650 0 |a Parasite antigens  |x Variation. 
650 0 |a Population genetics. 
650 1 2 |a Communicable Diseases  |x immunology 
650 2 2 |a Evolution, Molecular 
650 2 2 |a Genetics, Population 
650 2 2 |a Immunity  |x genetics 
650 2 |a Immunogenetics 
650 2 |a Antigens 
650 6 |a Immunogénétique. 
650 6 |a Relations hôte-parasite  |x Aspect génétique. 
650 6 |a Micro-organismes  |x Évolution. 
650 6 |a Antigènes. 
650 6 |a Évolution moléculaire. 
650 6 |a Antigènes parasitaires  |x Variation. 
650 6 |a Génétique des populations. 
650 7 |a MEDICAL  |x Immunology.  |2 bisacsh 
650 7 |a Population genetics  |2 fast 
650 7 |a Antigens  |2 fast 
650 7 |a Host-parasite relationships  |x Genetic aspects  |2 fast 
650 7 |a Immunogenetics  |2 fast 
650 7 |a Microorganisms  |x Evolution  |2 fast 
650 7 |a Molecular evolution  |2 fast 
650 7 |a Parasite antigens  |x Variation  |2 fast 
650 1 7 |a Moleculaire evolutie.  |2 gtt 
650 1 7 |a Immunologie.  |2 gtt 
650 1 7 |a Infectieziekten.  |2 gtt 
655 4 |a Fulltext. 
655 4 |a Internet Resource. 
776 0 8 |i Print version:  |a Frank, Steven A., 1957-  |t Immunology and evolution of infectious disease.  |d Princeton, : Princeton University Press, ©2002  |z 0691095949  |w (DLC) 2002018384  |w (OCoLC)48958206 
830 0 |a Online access: NCBI NCBI Bookshelf. 
856 4 0 |u https://jstor.uam.elogim.com/stable/10.2307/j.ctv15r5djw  |z Texto completo 
938 |a ProQuest Ebook Central  |b EBLB  |n EBL6326293 
938 |a Internet Archive  |b INAR  |n immunologyevolut0000fran_k5a1 
938 |a Project MUSE  |b MUSE  |n musev2_77710 
994 |a 92  |b IZTAP