The physical microbe : an introduction to noise, control, and communication in the prokaryotic cell /

Physical biology is a fusion of biology and physics. This book narrows down the scope of physical biology by focusing on the microbial cell; exploring the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at t...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Hagen, Stephen J. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2017]
Colección:IOP (Series). Release 4.
IOP concise physics.
Temas:
Prokaryotes.
Biophysics.
Prokaryotic Cells.
SCIENCE / Physics / General.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Preface : why the physical microbe?
  • 1. Introduction
  • 1.1. Diversity
  • 1.2. Size
  • 1.3. Energy
  • 1.4. Food
  • 1.5. Diffusion versus size
  • 2. Growth
  • 2.1. Exponential growth
  • 2.2. Stationary phase
  • 2.3. Lag phase and decline
  • 2.4. Balanced growth
  • 2.5. Partitioning of resources
  • 2.6. Individual cells in balanced growth
  • 3. Gene regulatory networks
  • 3.1. Transcription and translation
  • 3.2. Representation of networks and pathways
  • 3.3. Gene regulation basics
  • 3.4. Deterministic models for gene regulation
  • 4. Stochastic gene expression
  • 4.1. Variability at low copy number
  • 4.2. Modeling stochastic expression
  • 4.3. Bursts of gene expression
  • 4.4. Protein distributions with both transcription and translation
  • 4.5. Intrinsic and extrinsic noise
  • 4.6. Noise reduction and stability through feedback
  • 5. Phenotypic switching
  • 5.1. Two types of persisters
  • 5.2. Toxin-antitoxin systems and HipBA
  • 5.3. Bet-hedging by phenotypic switching
  • 6. Communication
  • 6.1. Chemical communication
  • 6.2. Pheromone triggered transitions of nonlinear systems
  • 6.3. Electrical communication
  • 7. Bacillus subtilis competence and sporulation : the final exam
  • 7.1. Competence decision by noisy autofeedback
  • 7.2. Phosphorelay sensor for sporulation
  • 7.3. A mutually repressing circuit inhibits competence
  • 7.4. Input from intercellular communication.

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