Multiscale modeling of vascular dynamics of micro- and nano-particles : application to drug delivery system /

Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Ye, Huilin (Mechanical engineer) (Autor), Shen, Zhiqiang (Mechanical engineer) (Autor), Li, Ying (Ph. D. in mechanical engineering) (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2019]
Colección:IOP (Series). Release 6.
IOP concise physics.
Temas:
Drug targeting.
Drug carriers (Pharmacy)
Nanoparticles > Therapeutic use.
Blood-vessels.
Biomechanics.
Biomedical materials > Mechanical properties.
Multiscale modeling.
Drug Delivery Systems.
Drug Carriers.
Nanoparticles > therapeutic use.
Blood Vessels > physiology.
Biocompatible Materials.
Biomechanical Phenomena.
Models, Anatomic.
Models, Biological.
Biophysics.
SCIENCE / Life Sciences / Biophysics.
Acceso en línea:Texto completo
Descripción
Sumario:Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow.
Notas:"Version: 20191201"--Title page verso.
"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.
Descripción Física:1 online resource (various pagings) : illustrations (some color).
Also available in print.
Público:Professional and scholarly.
Bibliografía:Includes bibliographical references.
ISBN:9781643277929
9781643277905
ISSN:2053-2571

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