The brain-bladder axis in tissue growth and remodelling /

Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate str...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Miftahof, Roustem N. (Autor), Cyron, Christian J. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2021]
Colección:IOP (Series). Release 21.
IPEM-IOP series in physics and engineering in medicine and biology.
IOP ebooks. 2021 collection.
Temas:
Bladder > Growth > Mathematical models.
Bladder > Innervation > Mathematical models.
Tissue remodeling > Mathematical models.
Neurobiology.
Urinary Bladder > physiology.
Urinary Bladder > innervation.
Regeneration.
Models, Theoretical.
Biomedical engineering.
Medical physics and biophysics.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Anatomical and morphological preliminaries
  • 1.1. Overview of the urinary bladder
  • 1.2. Detrusor muscle
  • 1.3. 'Pacemakers'
  • 1.4. Mechanosensation
  • 1.5. Afferent signalling
  • 1.6. Neuronal assemblies in the hypothalamus and adenohypophysis
  • 2. Continual models of the bladder tissue
  • 2.1. Single-phase models
  • 2.2. Multiphase models
  • 3. Models of the urinary bladder
  • 3.1. The bladder as shell structure
  • 3.2. The bladder as soft bioshell
  • 4. Signalling mechanisms
  • 4.1. L-Glutamate
  • 4.2. GABA
  • 4.3. Glycine
  • 4.4. Somatostatin
  • 4.5. Growth hormone releasing hormone
  • 4.6. Ghrelin
  • 4.7. Growth hormone
  • 4.8. Insulin-like growth factor-1
  • 4.9. Myogenesis
  • 4.10. Collagenesis
  • 5. Modelling the (intra)hypothalamic-pituitary axis
  • 5.1. Signal transduction
  • 5.2. Protein-tyrosine kinase receptor signalling
  • 5.3. Gene expression
  • 5.4. Hormonal interactions
  • 6. Growth and remodelling
  • 6.1. Biological preliminaries
  • 6.2. Continuum mechanics growth and remodelling models
  • 7. Brain-bladder axis in tissue growth and remodelling
  • 7.1. The architecture of the BBA
  • 7.2. Mathematical formulation of the BBA
  • 7.3. An Achilles' heel
  • 7.4. Simulation results
  • 8. What is to follow?
  • 8.1. Making a model reliable
  • 8.2. Model expansions in biomedicine
  • 8.3. Implementations in engineering.

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