Soft biological shells in bioengineering /

Soft Biological Shells in Bioengineeringintegrates existing experimental data to construct multiscale models of various organs of the human body--the stomach, gravid uterus, urinary bladder, the small and large intestine. These models are used asin silicoplatforms to study intricate physiological an...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Miftahof, Roustem (Autor), Akhmadeev, Nariman R. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2019]
Colección:IOP (Series). Release 6.
IOP expanding physics.
IPEM-IOP series in physics and engineering in medicine and biology
Temas:
Biomedical engineering.
Organs (Anatomy) > Mathematical models.
Elastic plates and shells.
Biomedical Engineering.
Tissues.
Models, Theoretical.
Elasticity.
TECHNOLOGY & ENGINEERING / Biomedical.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • part I. Fundamentals of soft biological shells. 1. Geometry of the surface
  • 1.1. Intrinsic geometry
  • 1.2. Extrinsic geometry
  • 1.3. Equations of Gauss and Codazzi
  • 1.4. General curvilinear coordinates
  • 1.5. Deformation of the surface
  • 1.6. Equations of compatibility
  • 2. Parameterization of shells of complex geometry
  • 2.1. Fictitious deformations
  • 2.2. Parameterization of the equidistant surface
  • 2.3. A single function variant of the method of fictitious deformation
  • 2.4. Parameterization of a complex surface in preferred coordinates
  • 2.5. Parameterization of complex surfaces on a plane
  • 3. Nonlinear theory of thin shells
  • 3.1. Deformation of a shell
  • 3.2. Forces and moments
  • 3.3. Equations of equilibrium
  • 4. Boundary conditions
  • 4.1. Geometry of the boundary
  • 4.2. Stresses on the boundary
  • 4.3. Static boundary conditions
  • 4.4. Deformations of the edge
  • 4.5. Equations of Gauss-Codazzi for the boundary
  • 5. Soft shells
  • 5.1. Deformation of a soft shell
  • 5.2. Principal deformations
  • 5.3. Membrane forces
  • 5.4. Principal membrane forces
  • 5.5. Corollaries of the fundamental assumptions
  • 5.6. Nets
  • 5.7. Equations of motion in general curvilinear coordinates
  • 5.8. Governing equations in orthogonal Cartesian coordinates
  • 5.9. Governing equations in cylindrical coordinates
  • 6. A continuum model of biological tissue
  • 6.1. Histomorphology of tissue
  • 6.2. A biocomposite as a mechanochemical continuum
  • 6.3. Biofactor Zij
  • 7. Neurons and neuronal assemblies
  • 7.1. The intrinsic regulatory system in the gut
  • 7.2. Interstitial cells of Cajal
  • 7.3. Electrical activity in neurons
  • 7.4. Neuronal circuits
  • 8. Chemical synapse
  • 8.1. A mathematical model
  • 8.2. cAMP-dependent pathway
  • 8.3. PLC-dependent pathway
  • 8.4. Co-localization and co-transmission
  • 9. Pharmacological modulations
  • 9.1. Biological preliminaries
  • 9.2. Modeling of competitive antagonist action
  • 9.3. Modeling of allosteric interaction
  • 9.4. Allosteric modulation of competitive agonist/antagonist action
  • 9.5. Modeling of a PDE-5 inhibitor
  • part II. Applications. 10. The stomach
  • 10.1. Anatomical considerations
  • 10.2. Mechanical properties
  • 10.3. Electromechanical phenomena
  • 10.4. General model postulates
  • 10.5. A functional unit
  • 10.6. Co-transmission in the SIP-ganglion unit
  • 10.7. The stomach as a soft biological shell
  • 10.8. Gastric accommodation
  • 10.9. The intrinsic regulatory system
  • 11. The small intestine
  • 11.1. Anatomical and physiological considerations
  • 11.2. General model postulates
  • 11.3. Investigations into intestinal smooth muscle
  • 11.4. The intestine as a soft biological shell
  • 11.5. Pharmacology of intestinal motility
  • 12. The large intestine (colon)
  • 12.1. Anatomical and physiological considerations
  • 12.2. The colon as a soft biological shell
  • 12.3. Pharmacology of colonic motility
  • 13. The gravid uterus
  • 13.1. Anatomical considerations
  • 13.2. A functional unit
  • 13.3. Electrophysiological properties
  • 13.4. Neuroendocrine modulators
  • 13.5. Coupling phenomena
  • 13.6. Crosstalk phenomena
  • 13.7. Biological changes in the gravid uterus
  • 13.8. Modeling of the gravid uterus
  • 13.9. General model postulates
  • 13.10. Investigations into the myometrium
  • 13.11. Co-transmission in the myometrium
  • 13.12. The gravid uterus as a soft biological shell
  • 13.13. Investigations into the gravid human uterus
  • 14. The urinary bladder
  • 14.1. Anatomical considerations
  • 14.2. The detrusor
  • 14.3. The neurohormonal regulatory system
  • 14.4. Functional states in the bladder
  • 14.5. Biomechanics of the detrusor
  • 14.6. Models of the bladder
  • 14.7. General model postulates
  • 14.8. Investigations into the detrusor
  • 14.9. Pharmacology of detrusor
  • 14.10. The urinary bladder as a soft biological shell
  • 14.11. Investigations into the urinary bladder
  • 15. Conclusion.

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