Introduction to pharmaceutical biotechnology. Volume 2, Enzymes, proteins and bioinformatics /

Introduction to Pharmaceutical Biotechnology, Volume 2 provides background information and knowledge on areas such as genes, enzymes and proteins. It is organized into these three important areas starting with the general properties, mechanisms, applications, production, immobilization, and purifica...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Bhatia, Saurabh (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2018]
Colección:IOP (Series). Release 5.
IOP expanding physics.
Temas:
Pharmaceutical biotechnology.
Biopharmaceutics.
Drug Therapy > trends.
Drug Industry > trends.
Genetic Phenomena.
Genetic engineering.
SCIENCE / Life Sciences / Biophysics.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Introduction to enzymes and their applications
  • 1.1. Introduction
  • 1.2. Properties of enzymes
  • 1.3. Catalysis
  • 1.4. The structure of enzymes
  • 1.5. Structural features : primary and secondary structures
  • 1.6. The mechanism of action of enzymes
  • 1.7. Catalysis via chymotrypsin
  • 1.8. Enzyme inhibition
  • 1.9. Pharmaceutical applications
  • 1.10. Plants and algae enzyme systems
  • 2. Technologies and procedures involved in enzyme production
  • 2.1. Introduction
  • 2.2. Enzyme production technology
  • 2.3. Procedures involved in enzyme production
  • 2.4. Recombinant proteins from algae
  • 3. Industrial enzymes and their applications
  • 3.1. Industrial enzymes
  • 3.2. Bacterial α-amylases
  • 3.3. Fungal α-amylases
  • 3.4. Bacterial proteases
  • 3.5. Fungal proteases
  • 3.6. Glucose isomerase (D-xylose ketol-isomerase; EC. 5.3.1.5)
  • 3.7. Penicillinase
  • 3.8. Chloramphenicol acetyltransferase
  • 3.9. Aminoglycoside antibiotic inactivating enzymes
  • 3.10. Fibrinolytic enzymes
  • 3.11. Biotechnological applications of enzymes
  • 4. Immobilization of enzymes
  • 4.1. Introduction
  • 4.2. Types of immobilization
  • 4.3. Genetic engineering for microbial enzyme production
  • 4.4. Protein studies for modification of commercial enzymes
  • 4.5. Enzyme and cell immobilization
  • 4.6. Immobilization methods
  • 4.7. Choice of immobilization technique
  • 4.8. Immobilization of cells
  • 4.9. Manufacture of commercial products
  • 4.10. Application of various immobilization techniques for algal bioprocesses
  • 5. Biosensors
  • 5.1. Introduction
  • 5.2. Principles of a biosensor
  • 5.3. Different types of biosensors
  • 5.4. Applications of biosensors
  • 6. Biotransformation and enzymes
  • 6.1. Introduction
  • 6.2. Types of biotransformation reactions
  • 6.3. Sources of biocatalysts and techniques for biotransformation
  • 6.4. Product recovery in biotransformations
  • 6.5. Application of biotransformation in the production of pharmaceutical products
  • 7. Introduction to genomics
  • 7.1. Introduction
  • 7.2. Characterizations in genomics
  • 7.3. Historical background
  • 7.4. Genome sequencing
  • 7.5. Understanding bioinformatics and sequencing
  • 7.6. Comparative genomics as a technique to understand evolution
  • 7.7. Gene estimation and counting
  • 7.8. Genomes : genome evolution
  • 7.9. Algae bioinformatics
  • 8. Basics of proteomics
  • 8.1. Introduction
  • 8.2. Types of proteomics
  • 8.3. Basic techniques involved in proteomics
  • 8.4. Complete proteome of Mycoplasma genitalium
  • 8.5. Architecture and design of the nuclear pore complex
  • 8.6. Functional genomics and systems biology
  • 8.7. Synthetic genomics
  • 9. Bioinformatics
  • 9.1. Introduction
  • 9.2. History of bioinformatics
  • 9.3. Sequences and nomenclature
  • 9.4. Investigation by means of bioinformatics tools
  • 10. Protein and enzyme engineering
  • 10.1. Protein and enzyme engineering
  • 10.2. Designing macromolecules
  • 10.3. Protein engineering versus enzyme engineering
  • 10.4. Protein engineering
  • 10.5. Foundation of protein (enzyme) engineering
  • 10.6. Basic assumptions for protein engineering
  • 10.7. Steps involved in protein engineering
  • 10.8. Methods of protein engineering
  • 10.9. Mutagenesis and selection of mutant enzymes
  • 10.10. Gene modifications or gene synthesis for protein engineering
  • 10.11. Multi-enzyme systems
  • 10.12. Chemical modification of enzyme
  • 10.13. Some early achievements of protein engineering.

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