Production, quality control and clinical applications of radiosynovectomy agents.

"Therapeutic radiopharmaceuticals play a major role in today's nuclear medicine with a positive impact on the diagnosis and treatment of diseases. One area of application is radiation synovectomy (RSV). Previously, RSV agents were often simple colloids. More recently, matrixes labelled wit...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Vienna : International Atomic Energy Agency, 2021.
Colección:IAEA radioisotopes and radiopharmaceuticals reports ; no. 3.
Temas:
Radiopharmaceuticals.
Synovectomy.
Nuclear medicine.
Radioisotopes > Therapeutic use.
Radiopharmaceuticals
Nuclear Medicine
Radiopharmaceutiques.
Synovectomie.
Médecine nucléaire.
Curiethérapie.
Nuclear medicine
Radioisotopes > Therapeutic use
Synovectomy
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • 1. INTRODUCTION
  • 1.1. Background
  • 1.2. Objectives
  • 1.3. Scope
  • 1.4. Structure
  • 2. RADIOSYNOVECTOMY IN THE TREATMENT OF SYNOVITIS
  • 2.1. Definition
  • 2.2. History
  • 2.3. Synovial joints
  • 2.4. Synovitis
  • 2.5. Rheumatoid arthritis
  • 2.6. Osteoarthritis
  • 2.7. Haemophilia
  • 2.8. Pigmented villonodular synovitis
  • 3. PATIENT SELECTION FOR RADIOSYNOVECTOMY
  • 3.1. Mechanism of action
  • 3.2. Indications
  • 3.3. Patient preference
  • 3.4. Indication for repeating radiosynovectomy
  • 3.5. Contraindications
  • 3.6. Adverse effects of radiosynovectomy
  • 4. Production of radionuclides required for RADIOSYNOVECTOMY
  • 4.1. Introduction
  • 4.2. Targeting
  • 4.2.1. 198Au
  • 4.2.2. 165Dy
  • 4.2.3. 169Er
  • 4.2.4. 166Ho
  • 4.2.5. 177Lu
  • 4.2.6. 32P
  • 4.2.7. 186Re
  • 4.2.8. 188Re
  • 4.2.9. 153Sm
  • 4.2.10. 117mSn
  • 4.2.11. 90Y
  • 5. Radiopharmaceuticals for RADIOSYNOVECTOMY
  • 5.1. Principle
  • 5.1.1. Radionuclide selection
  • 5.2. Characteristics of radionuclides used in radiosynovectomy
  • 5.3. Particles for radionuclides
  • 5.3.1. Particle selection
  • 5.3.2. Particle size
  • 5.3.3. Common particles used in radiosynovectomy
  • 5.4. Key particles used in radiosynovectomy
  • 5.4.1. Glass
  • 5.4.2. Chitosan
  • 5.4.3. Silicate
  • 5.4.4. Citrate
  • 5.4.5. Polylactic acid
  • 5.4.6. Hydroxyapatite
  • 5.4.7. Hydro- and solvothermal
  • 5.4.8. Solid state reactions
  • 5.4.9. Sol-gel process
  • 5.5. Preparation of radioactive particles
  • 5.5.1. Radiolabelling during particle preparation
  • 5.5.2. Radiolabelled particles after their preparation
  • 5.6. Key radionuclides evaluated for synovectomy
  • 5.6.1. 198Au
  • 5.6.2. 165Dy
  • 5.6.3. 169Er
  • 5.6.4. 166Ho
  • 5.6.5. 177Lu
  • 5.6.6. 32P
  • 5.6.7. 186Re
  • 5.6.8. 188Re
  • 5.6.9. 153Sm
  • 5.6.10. 117mSn
  • 5.6.11. 90Y
  • 6. Method used to prepare particles for RADIOSYNOVECTOMY
  • 6.1. Introduction
  • 6.2. Precipitation
  • 6.3. Emulsion: Evaporation or extraction of solvent
  • 6.4. Sol-gel process
  • 6.5. Spray drying
  • 6.6. Electrospraying
  • 7. Regulatory and Manufacturing Issues
  • 7.1. Radiopharmaceutical manufacturing elements
  • 7.1.1. Personnel
  • 7.1.2. Premises and equipment
  • 7.1.3. Documentation
  • 7.1.4. Training
  • 7.1.5. Quality assurance
  • 7.1.6. Quality control
  • 7.1.7. Responsibilities
  • 7.2. Quality evaluation of radiosynovectomy agents
  • 7.2.1. Quality control of the particle
  • 7.2.2. Quality control of radionuclides
  • 7.2.3. Quality control of radiolabelled particles
  • 7.3. Documentation
  • 7.3.1. General requirements
  • 7.3.2. Preparation procedures
  • 7.3.3. Batch records
  • 7.3.4. Staff training
  • 7.3.5. Validation of training
  • 7.3.6. Retraining
  • 7.3.7. Periodic review of training
  • 8. Standard operating procedure for RADIOSYNOVECTOMY
  • 8.1. Informed consent
  • 8.2. Diagnosis
  • 8.3. Facilities
  • 8.4. Preparation of patients
  • 8.5. Instrumentation
  • 8.6. Utensils

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