In vitro and in vivo development of a topical drug for the treatment of equine skin cancer - based on naturally occurring and synthetically modified substances in plane bark

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Weber, Lisa Annabel
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Göttingen : Cuvillier Verlag, 2021.
Colección:Wissenschaftliche Reihe der Klinik für Pferde.
Temas:
Horses > Diseases.
Skin > Cancer.
Bark.
Chevaux > Maladies.
Peau > Cancer.
Écorce.
bark (plant material)
Bark
Horses > Diseases
Skin > Cancer
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • LIST OF ABBREVIATIONS
  • SUMMARY
  • ZUSAMMENFASSUNG
  • 1. Introduction
  • 1.1. The equine malignant melanoma
  • 1.2. The equine sarcoid: an overview
  • 1.3. Topical drug application
  • 1.4. Naturally occurring substances in plane bark and their syntheticallymodified derivatives
  • 1.5. Hypotheses and aims of the thesis
  • 2. Manuscript I:Betulinic acid shows anticancer activity against equine melanoma cells andpermeates isolated equine skin in vitro
  • 2.1. Supplemental data
  • 3. Manuscript II:In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate asa topical treatment for equine skin cancer
  • 4. Manuscript III:Concentration profiles and safety of topically applied betulinic acid andNVX-207 in eight healthy horses
  • A randomized, blinded, placebocontrolled,crossover pilot study
  • 5. Manuscript IV:Effects of topically applied betulinic acid and NVX-207 on early stageequine melanoma
  • A prospective, randomized, double-blind, placebocontrolledpilot study
  • 6. General discussion
  • 6.1. Summarized findings
  • 6.2. Interpretation of the findings
  • 7. Major findings and conclusions
  • 8. Future perspectives
  • 9. References
  • Affidavit
  • Acknowledgements

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