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An introduction to p-glycoprotein /
"P-glycoprotein (P-gp), encoded by the multidrug-resistance (MDR)-1 gene is one of the best studied efflux transporters that is linked to multidrug resistance in cancer chemotherapies. P-gp belongs to the ATP-binding cassette (ABC) transporter family of proteins that utilizes energy derived fro...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science Publishers,
[2021]
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| Colección: | Pharmacology - research, safety testing and regulation
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Contents
- Preface
- Acknowledgments
- Chapter 1
- Introduction: Structure and Function
- Abstract
- Introduction
- Structure
- Topological Features of P-gp
- Functions of P-Glycoprotein
- Potential Mechanism of Action for Drug Disposition by P-Glycoprotein (P-gp)
- Molecular and Biological Functions of P-gp
- Role of P-gp in Various Pathologies
- Interactome Analysis of P-Gp and Associated Metabolic Pathways Using Protein Interaction Analysis and Pathway Enrichment Analysis
- Conclusion and Future Perspectives
- References
- Chapter 2
- Relative Distribution of P-glycoprotein (P-gp) and its Pharmacological Relevance
- Abstract
- Introduction
- Physiological Distribution of P-glycoprotein in Normal and Diseased Conditions
- Intestinal Epithelium
- Liver
- Kidneys
- Blood-Brain Barrier (BBB)
- Pharmacokinetics and Pharmacological Relevance
- Efflux Mechanisms and Effect of P-gp in Oral Bioavailability
- Efflux Mechanisms
- Effect on Oral Bioavailability
- Cerebral Disorders
- Alzheimer's Disease
- Epilepsy
- Tumors
- Ovarian Cancer
- Autoimmune Disorders
- Systemic Lupus Erythematosus (SLE)
- Rheumatoid Arthritis
- Role of P-gp in Development of Multidrug Resistance (MDR)
- Conclusion
- Declaration of Competing Interests
- Acknowledgments
- References
- Chapter 3
- P-gp Pathophysiology:
- Post-Translational Modification
- and Affecting Signaling Cascades
- Abstract
- Introduction
- P-gp as a Lipid Flippase
- P-gp as a Vacuum Cleaner
- Effect of P-gp in Pathology
- Pathophysiology of Various Diseases Related to P-gp
- Signaling Transduction
- Pathway of P-gp Intracellular Trafficking
- Post-translational Moifications of Transporters
- Conclusion
- References
- Chapter 4
- Mechanistic Comprehension towards the Role of P-Glycoprotein in Limiting the Pharmacokinetic and Pharmacological Efficacy of Drugs
- Abstract
- Introduction and Background
- Structure and Function of P-gp
- P-gp and Drug Pharmacokinetics/Bioavailability
- Effect of P-gp on Drug Absorption
- Effect of P-gp Upon Drug Distribution
- Effect of P-gp Upon Drug Metabolism
- Effect of P-gp Upon Drug Elimination
- Pathophysiology Behind P-gp and Drug Interaction
- Conclusion and Future Perspectives
- Acknowledgments
- Conflict of Interest
- References
- Chapter 5
- P-Glycoprotein, a Biological and Medicinal Chemistry/Radiochemistry Point of View
- Abstract
- Introduction
- A Biological Point of View: The P-Gp Interacting Mechanism
- Substrates, Inhibitors and Modulators: The Pivotal Role of P-Gp in the Therapy and Diagnosis of Pathological Conditions
- P-Glycoprotein Inducers and Activators
- A Medicinal Chemistry Point of View: Development of P-gp Interacting Compounds
- P-Gp Radiotracers
- P-gp Substrates
- P-gp Inhibitors
- Conclusion
- Conflict of Interest
- References
- Chapter 6
- P-Glycoprotein: A New Insight in