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Exercises in Organic Synthesis Based on Synthetic Drugs
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore :
Bentham Science Publishers,
2020.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover
- Title
- Copyright
- End User License Agreement
- Contents
- Preface
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- How to Build a Drug: Exercises Based on the Concept of Retrosynthetic Analysis
- INTRODUCTION
- PROTECTIVE GROUPS
- EXERCISES 1 TO 4
- RETROSYNTHETIC ANALYSIS
- EXERCISE 1
- TWO SYNTHONS = DRUG
- Example
- Answer
- EXERCISES
- Answers
- EXERCISE 2
- EPOXIDES
- Example
- Answer
- EXERCISES
- Answers
- EXERCISE 3
- PIPERAZINE AND RELATED SUBSTANCES
- Examples
- Answers
- EXERCISES
- Answers
- EXERCISE 4
- ALDEHYDES
- Examples
- Answers
- EXERCISES
- Answers
- CONCLUSION OF THE EXERCISES 1 TO 4 (RETROSYNTHETIC ANALYSIS)
- Organizing Synthetic Routes and Identifying Reagents
- EXERCISES 5 TO 8
- INTRODUCTION
- EXERCISE 5
- ORGANIZING SYNTHETIC ROUTES
- Example
- Answer
- EXERCISES
- RUTHENIUM AND ITS COMPLEXES AS OXIDANTS
- MECHANISM OF WITTIG-HORNER REACTION
- EXERCISE 6
- IDENTIFYING REAGENTS
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION OF THE EXERCISES 5 AND 6 (ORGANIZING SYNTHETIC ROUTES AND IDENTIFYING REAGENTS)
- Identifying Drug Structure and Completing the Gaps
- EXERCISE 7
- IDENTIFYING DRUG STRUCTURE
- Examples
- Answers
- EXERCISES
- Answers
- EXERCISE 8
- COMPLETING THE GAPS
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION OF EXERCISES 7 AND 8 (IDENTIFYING DRUG STRUCTURE AND COMPLETING THE GAPS)
- BIBLIOGRAPHIC DATA OF EXERCISES 1 TO 9
- Heteroaromatic Substances
- FIVE-MEMBERED RINGS
- SIX-MEMBERED RINGS
- FUSED SYSTEMS
- Example
- Answer
- MECHANISM OF REACTION
- EXERCISES
- Answers
- CONCLUSION
- Hydrazine and its Derivatives
- INTRODUCTION
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION
- Nitriles
- INTRODUCTION
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION
- Combinatorial Chemistry
- INTRODUCTION
- Example
- Answer
- MECHANISM OF REACTION
- EXERCISES
- Answers
- CONCLUSION
- REFERENCE
- Multicomponent Reaction (MCR)
- INTRODUCTION
- Example
- Answer
- Important Note
- EXERCISES
- Answers
- CONCLUSION
- Click Chemistry
- INTRODUCTION
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION
- SUGGESTIONS FOR READING
- Fluorine in Drug Discovery
- INTRODUCTION
- FLUORINATION REAGENTS
- Nucleophilic Fluorination for the Introduction of Fluorine Atom NaF, KF, HF, and Bu4NF
- Diethylaminosulfur Trifluoride (DAST)
- Nucleophilic Fluorination for the Introduction of the Trifluoromethyl Group
- Eletrophilic Fluorination for the Introduction of Fluorine Atoms
- Electrophilic Fluorination for the Introduction of the Trifluoromethyl Group
- Radical Fluorination
- CLASSICAL EXAMPLES OF THE IMPORTANCE OF FLUORINE IN DRUG DEVELOPMENT
- Fluoroquinolone
- Sitagliptin
- Odanacatib
- Celecoxib
- Example
- Answer
- EXERCISES
- Answers
- CONCLUSION
- REFERENCES