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Pizzo and Poplack's pediatric oncology
"This authoritative reference is a comprehensive resource on the biology and genetics of childhood cancer as well as its diagnosis, multimodal treatment, as well as long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Philadelphia
Wolters Kluwer Health
[2021]
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| Edición: | Eighth edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page
- Copyright Page
- Section 1 Biological Basis of Childhood Cancer
- 1 Epidemiology of Childhood Cancer
- Cancer Surveillance and Descriptive Epidemiology
- Analytic Epidemiology
- Summary and Future Considerations
- 2 Heredity and Childhood Cancer
- Constitutional Chromosomal Abnormalities
- Structural Chromosomal Abnormalities
- Overgrowth Disorders and Imprinting Errors
- Autosomal Dominant Disorders
- Autosomal Recessive Disorders
- Issue in Genetic Testing for the Pediatric Oncology Patient
- 3 Molecular and Genetic Basis of Childhood Cancer
- General Nature of Cancer-Associated Genetic Aberrations
- Comprehensive Analysis of the Cancer Genome
- Germline Mutations
- Somatically Acquired Chromosomal Aberrations and Mutation
- Gross Chromosomal Rearrangements
- Oncogenic Consequences of Gross Chromosomal Rearrangements-General Themes
- Chromosomal Translocations Lead to Activation of Proto-Oncogenes and Generation of Oncogenic Fusion Genes
- Chromosomal Deletion Leads to Inactivation of Tumor Suppressor Genes
- Gene Amplification
- Point Mutations Leading to Gene Activation or Inactivation
- Comprehensive Genomic Studies of Pediatric Tumors
- Mechanisms of Malignant Cell Transformation, Growth, and Clonal Expansion
- Outlook for Molecularly Targeted Therapies
- Summary
- 4 Biology of Childhood Cancer
- Gene Regulation
- Protein Regulation
- Signal Transduction
- Cell Proliferation
- Programmed Cell Death
- Cancer Metabolism
- Metastasis and the Tumor Microenvironment
- 5 Tumor Immunology of Childhood Cancer
- Overview of the Immune System
- Modern Concepts of Immune Surveillance
- T-Cell Recognition of Cancer
- Innate Immune Cells and the Tumor Microenvironment
- Immune Function in Cancer Patients
- Immunotherapy of Cancer
- Summary and Future Directions.
- Basic Principles for the Clinical Development of Molecularly Targeted Agents
- Therapies Targeted to Apoptosis Pathways
- Targeting Extracellular Survival Signaling Pathways
- Targeting Development, Differentiation, and Other Intracellular Processes
- Targeting Angiogenesis
- Conclusions
- 13 General Principles of Hematopoietic Stem Cell Transplantation
- Autologous Transplantation-High-Dose Chemotherapy with Hematopoietic Stem Cell (Hsc) Rescue
- Allogeneic Transplantation
- Allogeneic Hematopoietic Stem Cell Transplantation Preparative Regimens
- Transplantation for Leukemia
- Transplantation for Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL)
- Transplantation for Solid Tumors
- Complications After Hematopoietic Stem Cell Transplantation
- Late Effects After Hematopoietic Stem Cell Transplantation
- Future Directions
- 14 General Principles of Radiation Oncology
- Biologic Basis of Radiation Therapy
- Physical Basis of Radiation Therapy
- Interactions of Radiation Therapy and Chemotherapy
- Radiation Effects on Normal Tissues
- 15 General Principles of Surgery
- Preoperative Considerations for the Oncologist
- Perioperative Considerations for the Oncologist
- Minimally Invasive Surgery
- Section 4 Management of Common Cancers of Childhood
- 16 Acute Lymphoblastic Leukemia
- Epidemiology
- Genetic Risk Factors
- Environmental Risk Factors
- Pathogenesis
- Classification of Acute Lymphoblastic Leukemia
- Molecular Genomics of Acute Lymphoblastic Leukemia
- Pharmacogenetics
- Clinical Presentation
- Assessing Treatment Response
- Prognostic Factors
- Treatment
- Treatment of Relapse
- Late Effects of Treatment
- Future Challenges
- 17A Acute Myeloid Leukemia and Myelodysplastic Syndromes
- Historical Background and Definitions.
- Epidemiology of Pediatric Acute Myeloid Leukemia and Myelodysplastic Syndrome
- Biologic Basis of Acute Myeloid Leukemia and Myelodysplastic Syndrome: From Normal Progenitors to Leukemia
- Methodologies for Classifying Myeloid Malignancies
- Defining Subtypes: Evolution of Diagnostic Classification of Myeloid Malignancies
- Clinical and Laboratory Presentation
- Prognostic Factors and Implications of Risk Group Stratification on Treatment
- Evolution of Risk Adapted Therapy
- Unique Aml Subtypes and Settings
- The Treatment of Relapsed or Refractory Acute Myeloid Leukemia
- Survivorship
- 17B Myeloproliferative Neoplasms of Childhood
- Chronic Myeloid Leukemia
- Juvenile Myelomonocytic Leukemia
- Polycythemia Vera and Essential Thrombocythemia
- 18 Hodgkin Lymphoma
- Biologic Considerations
- Epidemiology, Pathogenesis &
- Pathology
- Clinical Presentation
- Treatment and Outcome
- Nodular Lymphocyte Predominant Hodgkin Lymphoma
- Approach to Patients with Primary Refractory Disease or Relapse of Hodgkin Lymphoma
- Late Effects
- Future Considerations
- 19 Malignant Non-Hodgkin Lymphomas in Children
- Non-Hodgkin Lymphoma Overview
- NHL Cellular Classifications: Specific Biologic and Clinical Considerations
- Conclusions
- Management Summary
- 20 Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies
- Viral Pathogens and the Development of Malignancies
- Epstein-Barr Virus and Malignancies
- Human herpesvirus-8 and Malignancies in Immunodeficient Patients
- Malignancies in Primary Immunodeficiencies
- Secondary Immunodeficiency and Cancer
- Malignancies in the Posttransplant Patient
- Summary
- 21 Histiocytoses
- Langerhans Cell Histiocytosis
- Hemophagocytic Lymphohistiocytosis
- Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)
- Juvenile Xanthogranuloma.
- Malignant Histiocytic Diseases
- Summary
- Management Summary
- 22A Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System
- Epidemiology
- Inherited Syndromes Associated with Central Nervous System Tumors
- Ionizing Radiation and Central Nervous System Tumors
- Pathologic Classification of Central Nervous System Tumors
- Clinical Presentation
- Neuroimaging in Pediatric Central Nervous System Tumors: Current Status and Future Directions
- Neurosurgery: Diagnosis and Treatment
- Radiation Therapy
- Principles of Chemotherapy
- Ependymoma
- Low-Grade Gliomas
- Tumors of the Optic Pathway
- Supratentorial High-Grade Gliomas
- Brainstem Gliomas
- Craniopharyngioma
- Choroid Plexus Neoplasms
- Intramedullary Spinal Cord Tumors
- Sequelae of Treatment
- 22B Tumors of the Central Nervous System: Embryonal and Pineal Region Tumors
- Embryonal Tumors
- Medulloblastoma
- Atypical Teratoid/Rhabdoid Tumor
- Embryonal Tumors with Multilayered Rosettes
- Other Rare Embryonal Tumors
- Pineal Region Tumors
- Germ Cell Tumors
- 23 Neuroblastoma
- Epidemiology
- Genetic Predisposition
- Molecular Pathogenesis
- Pathology
- Clinical Presentation
- Paraneoplastic Syndromes
- Clinical and Laboratory Evaluation
- Staging and Treatment Response
- Prognostic Considerations
- Principals of Initial Therapy
- Late Effects
- Future Considerations
- 24 Renal Tumors
- Epidemiology
- Genetics and Molecular Biology
- Pathology
- Clinical Presentation and Diagnostic Workup
- Prognostic Factors
- Treatment of Wilms Tumor
- Clear Cell Sarcoma of the Kidney
- Malignant Rhabdoid Tumor
- Renal Cell Carcinoma
- Congenital Mesoblastic Nephroma
- 25 Rhabdomyosarcoma
- Epidemiology and Genetic Susceptibility
- Molecular Biology
- Animal Models
- Pathology
- Patterns of Spread and Clinical Presentation.