Medicinal Chemistry of Drugs Affecting the Nervous System

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The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second vol...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Faruk, M. O., Philip, Ashok E.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore : Bentham Science Publishers, 2020.
Colección:Medicinal Chemistry for Pharmacy Students Ser.
Temas:
Neuropharmacology.
Autonomic nervous system > Effect of drugs on.
Central nervous system > Effect of drugs on.
Pharmaceutical chemistry.
Neuropharmacology
Chemistry, Pharmaceutical
Neuropharmacologie.
Système nerveux autonome > Effets des médicaments sur.
Système nerveux central > Effets des médicaments sur.
Chimie pharmaceutique.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title
  • Copyright
  • End User License Agreement
  • Contents
  • Preface
  • List of Contributors
  • Drugs Affecting the Cholinergic System
  • Cory R. Theberge1, Kim Lindsey-Goodrich2 and Ashok E. Philip3,*
  • HISTORICAL PERSPECTIVES
  • INTRODUCTORY CONCEPTS
  • Choline and Acetylcholine
  • Acetylcholine and Neurotransmission
  • Cholinergic Neurochemistry: ACh Biosynthesis, Storage, Release, and Metabolism
  • Cholinergic Receptors
  • Muscarinic and Nicotinic Subtypes
  • Clinical Use of Acetylcholine
  • MUSCARINIC RECEPTOR AGONISTS
  • MUSCARINIC RECEPTOR ANTAGONISTS (ANTICHOLINERGICS)
  • Donepezil (Aricept®)
  • Pharmacokinetics
  • Side effects/Drug Interactions
  • Rivastigmine (Exelon®) 2000, Oral
  • 2008, Patch
  • Pharmacokinetics
  • Side effects/Drug Interactions
  • Galantamine (Razadyne®) 2001
  • Pharmacokinetics
  • Side effects/Drug-interactions
  • NMDA Receptor Antagonist: Memantine (Namenda®) 2003
  • Pharmacokinetics
  • Side effects/Drug interactions
  • Place in Therapy
  • CASE STUDY
  • What therapeutic modifications would you make at this time and why?
  • Drug Discovery Case Study
  • The Quaternary Advantage
  • Ipratropium and the Kinetic Selectivity of Tiotropium
  • STUDENT SELF STUDY GUIDE
  • PRACTICE QUESTIONS
  • NOTES
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Drugs Affecting Adrenergic System
  • M. O. Faruk1,* and Les Ramos2
  • HISTORICAL BACKGROUND
  • THE INTRODUCTORY CONCEPTS
  • Adrenergic Neurotransmitters
  • Adrenergic Receptors (ARs)
  • DRUGS AFFECTING ADRENERGIC SYSTEM: STRUCTURES, ACTIVITY, METABOLISM AND RELATED THERAPEUTIC CONSIDERATIONS
  • The Antiadrenergics Affecting Synthesis, Storage, or Release of NE (Fig. 7)
  • Metyrosine
  • Reserpine
  • Mechanism of Action
  • Pharmacokinetics

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