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Medicinal Chemistry of Drugs Affecting the Nervous System

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second vol...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Faruk, M. O., Philip, Ashok E.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore : Bentham Science Publishers, 2020.
Colección:Medicinal Chemistry for Pharmacy Students Ser.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Medicinal Chemistry of Drugs Affecting the Nervous System  |h [electronic resource]. 
260 |a Singapore :  |b Bentham Science Publishers,  |c 2020. 
300 |a 1 online resource (406 p.). 
490 1 |a Medicinal Chemistry for Pharmacy Students Ser. 
500 |a Description based upon print version of record. 
505 0 |a Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Drugs Affecting the Cholinergic System -- Cory R. Theberge1, Kim Lindsey-Goodrich2 and Ashok E. Philip3,* -- HISTORICAL PERSPECTIVES -- INTRODUCTORY CONCEPTS -- Choline and Acetylcholine -- Acetylcholine and Neurotransmission -- Cholinergic Neurochemistry: ACh Biosynthesis, Storage, Release, and Metabolism -- Cholinergic Receptors -- Muscarinic and Nicotinic Subtypes -- Clinical Use of Acetylcholine -- MUSCARINIC RECEPTOR AGONISTS -- MUSCARINIC RECEPTOR ANTAGONISTS (ANTICHOLINERGICS) 
505 8 |a Donepezil (Aricept®) -- Pharmacokinetics -- Side effects/Drug Interactions -- Rivastigmine (Exelon®) 2000, Oral -- 2008, Patch -- Pharmacokinetics -- Side effects/Drug Interactions -- Galantamine (Razadyne®) 2001 -- Pharmacokinetics -- Side effects/Drug-interactions -- NMDA Receptor Antagonist: Memantine (Namenda®) 2003 -- Pharmacokinetics -- Side effects/Drug interactions -- Place in Therapy -- CASE STUDY -- What therapeutic modifications would you make at this time and why? -- Drug Discovery Case Study -- The Quaternary Advantage -- Ipratropium and the Kinetic Selectivity of Tiotropium 
505 8 |a STUDENT SELF STUDY GUIDE -- PRACTICE QUESTIONS -- NOTES -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Drugs Affecting Adrenergic System -- M. O. Faruk1,* and Les Ramos2 -- HISTORICAL BACKGROUND -- THE INTRODUCTORY CONCEPTS -- Adrenergic Neurotransmitters -- Adrenergic Receptors (ARs) -- DRUGS AFFECTING ADRENERGIC SYSTEM: STRUCTURES, ACTIVITY, METABOLISM AND RELATED THERAPEUTIC CONSIDERATIONS -- The Antiadrenergics Affecting Synthesis, Storage, or Release of NE (Fig. 7) -- Metyrosine -- Reserpine -- Mechanism of Action -- Pharmacokinetics 
520 |a The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second volume of the series and it presents 8 chapters focusing on a comprehensive account of drugs affecting the nervous system. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detail structure activity relationships and metabolism as w. 
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650 0 |a Neuropharmacology. 
650 0 |a Autonomic nervous system  |x Effect of drugs on. 
650 0 |a Central nervous system  |x Effect of drugs on. 
650 0 |a Pharmaceutical chemistry. 
650 2 |a Neuropharmacology 
650 2 |a Chemistry, Pharmaceutical 
650 6 |a Neuropharmacologie. 
650 6 |a Système nerveux autonome  |x Effets des médicaments sur. 
650 6 |a Système nerveux central  |x Effets des médicaments sur. 
650 6 |a Chimie pharmaceutique. 
650 7 |a Central nervous system  |x Effect of drugs on.  |2 fast  |0 (OCoLC)fst00850741 
650 7 |a Neuropharmacology.  |2 fast  |0 (OCoLC)fst01036458 
650 7 |a Pharmaceutical chemistry.  |2 fast  |0 (OCoLC)fst01060115 
700 1 |a Faruk, M. O. 
700 1 |a Philip, Ashok E. 
776 0 8 |i Print version:  |a Faruk, M. O.  |t Medicinal Chemistry of Drugs Affecting the Nervous System  |d Singapore : Bentham Science Publishers,c2020  |z 9789811454059 
830 0 |a Medicinal Chemistry for Pharmacy Students Ser. 
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880 |6 500-00/(S  |a Therapeutic Evaluation of the Imidazoline α Adrenergic Agonists 
880 8 |6 505-00/(S  |a Guanethidine and Guanadrel -- Direct-Acting Sympathomimetic Agents -- The General Mechanism and SAR of β-Phenylethylamine Derivatives (Direct and Indirect Acting Agonists) -- Sar 1 -- Sar 2 -- Sar 3 -- Sar 4 -- Sar 5 -- Sar 6 -- Sar 7 -- Sar 8 -- Sar 9 -- Therapeutic Evaluation of the β-Phenylethylamine Direct Acting Adrenergic Agonists -- β2 Adrenergic Agonist and Cardiac Function -- Long Acting β2-Adrenoceptor Agonists (LABAs) -- β3 Adrenergic Receptor Agonist -- The General SAR of Imidazolines (α Adrenergic Agonist and Antagonists) -- Sar 1 -- Sar 2 -- Sar 3 
880 8 |6 505-00/(S  |a Acetylcholinesterase (AChE) Inhibitors -- Reversible Noncovalent Inhibitors -- Reversible Covalent Inhibitors -- Irreversible Covalent Inhibitors -- NEUROMUSCULAR BLOCKING AGENTS -- Depolarizing Muscle Nicotinic Receptor Neuromuscular Blocking Agents -- Non-depolarizing Muscle Nicotinic Receptor Neuromuscular Blocking Agents -- Ganglionic-Nicotinic Receptor Blocking Agents -- TREATMENT OF ALZHEIMER'S DISEASE (AD) -- Epidemiology -- Pathophysiology -- β-Amyloid Hypothesis -- Cholinergic Hypothesis -- Other Hypothesis -- Pharmacotherapy -- Acetyl Cholinesterase (AChE) Inhibitors 
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