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Fetal Hemoglobin
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science Publishers, Incorporated,
2020.
|
| Colección: | Recent Advances in Hematology Research Ser.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro
- Contents
- Preface
- Survival needs subsistence
- Acknowledgments
- List of Abbreviations
- Chapter 1
- Hemoglobin: A Biochemical and Molecular Overview
- Abstract
- Introduction
- Hemoglobin Research and Era of Molecular Medicine
- A Brief History of Hemoglobin Research
- Hemoglobin Heterogeneity
- Evolutionary Relationship between the Various Hemoglobin Genes
- Hemoglobin Structure
- The Structure of Adult Hemoglobin
- Primary Structure
- Secondary Structure
- Tertiary Structure
- Quaternary Structure
- The Structure of Fetal Hemoglobin
- The Structure of Embryonic Hemoglobin
- Hemoglobin Synthesis
- Hemoglobin Function
- Gaseous Transport
- Carbon Monoxide as a Ligand of Hemoglobin
- Nitric Oxide and Hemoglobin Interactions
- Allosteric Effect
- What Is Allosteric Effect?
- Ligand Binding and Altered Oxygen Affinity
- Hemoglobin Genetics
- Conclusion
- Acknowledgments
- References
- Chapter 2
- Prenatal and Postnatal Hemoglobins: Formation and Gaseous Exchange
- Abstract
- Hemoglobin Structure: An Overview
- Types of Hemoglobin
- Genetics Behind Globin Composition of Hb
- Hemoglobin Functions
- Gaseous Transport
- Transport of Oxygen
- Oxygen Dissociation Curve
- Factors Affecting Oxygen Dissociation
- Transport of Carbon Dioxide
- Non-Gaseous Transport Functions of Hb
- Metabolism of Hemoglobin
- Synthesis of Hb under Normal Conditions
- Catabolism of Hemoglobin
- Hemoglobin Synthesis in Utero
- Developmental Hematopoiesis/Site and Type of Hematopoiesis
- Genetic Controls of Hemoglobin Synthesis
- Embryonic to Fetal Hb Switch
- Fetal to Adult Hemoglobin Switch
- Unique Properties of HbF
- Diffusion of Oxygen Through the Placental Membrane
- Other Properties
- Hemoglobinopathies Causing Excess Hb F Formation
- Hereditary Persistence of Fetal Hemoglobin (HPFH)
- Sickle Cell Anemia
- Beta Thalassemia
- Other Conditions Causing Elevated HbF
- References
- Chapter 3
- An Introduction to Fetal Hemoglobin and Its Characteristics
- Abstract
- Introduction
- Fetal Hemoglobin: A Brief Look of Early Research
- Fetal Hemoglobins in Other Animals
- F-Cells
- Function of HbF
- Measurement of Fetal Hemoglobin
- Structure of Fetal Hemoglobin
- Hemoglobin Variants, HbF and Hemoglobin Barts
- HbF in Pregnancy and Development
- Conditions Associated with Elevated Fetal Hemoglobin Levels
- Hemoglobin F and Hereditary Persistence of Fetal Hemoglobin (HPFH)
- Sickle Cell Anemia
- Thalassemia
- Marrow Hypoplasia
- Aplastic Anemia
- Leukemia
- Thyrotoxicosis
- Acquired Increases in HbF Levels
- Therapeutics
- References
- Chapter 4
- Regulation of the Gamma Globin Gene: Current Concepts and Perspectives
- Abstract
- Introduction
- The Role of Molecular Factors in the Regulation of Gamma Globin
- BCL11A
- LRF/ZBTB7A/Pokemon
- GATA1
- KLF1
- MYB
- Cis-Acting Elements
- Epigenetic Control