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FRONTIERS IN NATURAL PRODUCT CHEMISTRY VOLUME 5

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substan...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: ATTA UR-RAHMAN
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [Place of publication not identified] BENTHAM Science PUBLISHER, 2019.
Temas:
Acceso en línea:Texto completo

MARC

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505 0 |a Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Inhibition of Monoamine Oxidase (MAO) via Green Tea Extracts: Structural Insights of Catechins as Potential Inhibitors of MAO -- Gemma R. Topaz1,2, Astrid March1, Victor Epiter-Smith1 and Kimberly A. Stieglitz1,* -- 1. INTRODUCTION -- 1.1. The Potential of Green Tea for Health and Disease Prevention -- 2. CHARACTERIZATION OF CATECHINS -- 2.1. Characteristics and Types -- 2.2. Catechins as Inhibitors -- 2.3. Effects of Catechins on Depression -- 3. CHARACTERIZATION OF MONOAMINE OXIDASES 
505 8 |a 3.1. Functional Characteristics -- 3.2. Mechanistic Comparison of Monoamine Oxidases -- 3.3. Diseases of the Nervous System: Fluctuations in MAO Activity -- 3.4. Monoamine Oxidase Inhibitors: A Pharmaceutical Approach -- 3.5. Current Pharmacological Agents as MAOIs -- 3.6. Pharmacotherapy of Monoamine Oxidase-Associated Disorders -- 3.7. Monoamine Reuptake Inhibitors: Mechanisms of Inhibitor Action -- 3.8. MAOIs: Mechanisms of Inhibitor Action-Nonselective and Selective Inhibition -- 3.9. Adverse Effects of Conventional MAOIs: Clinical Considerations and Toxicity 
505 8 |a 3.10. The Need for Additional (natural) Inhibitors of MAO -- 3.11. The Proposed Benefits of Catechins as Natural Inhibitors of MAO -- 4. HIGH THROUGHPUT SCREENING STRATEGIES -- 4.1. Non-Fluorescence-based Assays -- 4.2. Fluorescence-based Assays: The Role of the Fluorescent Probe -- 4.3. Fluorescence-based Assays: Inhibition Assays -- 4.4. High Throughput Screening with Enzyme-Linked Fluorescent Assays -- 5. EGCG AS AN INHIBITOR OF MAOA AND MAOB -- 5.1. EGCG Content in Green Tea and Recommended Dosage -- 5.2. Preliminary Studies -- 5.3. Inhibition of MAO via Green Tea Extracts 
505 8 |a 5.4. Molecular Docking Studies -- 5.5. Molecular Docking of Control Inhibitors -- 5.6. Molecular Docking of Catechin EGCG -- 6. PHARMACOKINETICS AND ADVERSE EFFECTS OF GREEN TEA CATECHINS -- 6.1. Absorption, Distribution, Metabolism, and Excretion of Green Tea Catechins -- 6.2. Adverse Effects of Green Tea Consumption: Toxicity and Drug Interactions -- CONCLUDING REMARKS -- ABBREVIATIONS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- REFERENCES -- Sesquiterpene Lactone Cynaropicrin as Novel Inhibitor of Bcr-Abl Fusion Oncogene Expression 
505 8 |a Maria Cristina Caroleo*, Francesca Aiello, Erika Cione and Maria Luisa Di Gioia -- INTRODUCTION -- Tyrosine Kinase Inhibitors (TKIs) -- Sesquiterpene Lactone Cynaropicrin Extraction -- Sesquiterpene Lactone Cynaropicrin Derivatives and Structure-Activity Relationship (SAR) Studies -- Cynaropricrin as Co-adjuvant CML Therapy -- CONCLUDING REMARKS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGMENT -- REFERENCES -- Effects of Dietary Polyphenols on Chronic Diseases: Epidemiological Data and Molecular Mechanisms of Action -- Kazuo Yamagata* -- 1. INTRODUCTION 
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