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190209s2019 onc ob 001 0 eng d |
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|a 1084557417
|a 1084685744
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|a 1773618318
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|a 9781773618319
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|a (OCoLC)1085180618
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|a QP552.M44
|b A38 2019
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|a 572.696
|2 23
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|a UAMI
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|a Advances in structure of membrane proteins /
|c edited by: Aleksei Anatoliyovych Stepanenko.
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|a Oakville, ON :
|b Delve Publishing,
|c 2019.
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|a 1 online resource (450 pages)
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|a text
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|a Cover; Half Title Page; Title Page; Copyright Page; Declaration; About the Editor; Table of Contents; List of Contributors; List of Abbreviations; Preface; Chapter 1 Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy; Abstract; Introduction; Structure, Basic Properties and Activation of CNG Channels; Signal Transduction in Photoreceptors; In Vivo Analysis of CNG Channel Function: Analysis of Genetic Mouse Models and Human Channelopathies; Gene Therapy for the Treatment of CNG Channelopathies; Gene Therapy for CNG Channel-Linked RP
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|a Gene Therapy for CNG Channel-Linked ACHMReferences; Chapter 2 Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding; Abstract; Introduction; Primary Structures of GnRH Receptors; The Three-Dimensional Structure of the GnRH Receptor; Ligand-Binding Interactions; Concluding Remarks; Author Contributions; Footnotes; References; Chapter 3 Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design; Abstract; Introduction; Booming Age of GPCR Structural Biology; Insights Into GPCR Ligand Space
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|a Chapter 5 Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist BindingAbstract; Introduction; Structural Probing of the A3 Adenosine Receptor; Molecular Modeling of the A3 Adenosine Receptor; Library Screening to Discover Novel Ligands of the A3 Adenosine Receptor; Receptor Dimerization; Conclusions; Acknowledgments; References; Chapter 6 Methods used to Study the Oligomeric Structure of G-protein-coupled Receptors; Abstract; Introduction; Methods to Study Oligomers of GPCRs; BN-PAGE; Concluding remarks; Abbreviations; Funding; References; Abstract.
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|a Includes bibliographical references and index.
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|a Print version record.
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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|a Membrane proteins
|x Structure.
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|a Protéines membranaires
|x Structure.
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|a Stepanenko, Aleksei Anatoliyovych.
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|i Print version:
|a Stepanenko, Aleksei Anatoliyovych.
|t Advances in structure of membrane proteins.
|d Ashland : Delve Publishing, ©2019
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856 |
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|z Texto completo
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|6 505-00/(S
|a Cheminformatics-Based Paradigms In GPCR Drug DiscoverySummary of Cheminformatics Softwares/Tools Utilized In GPCR Drug Discovery; Conclusions; Author Contributions; Conflict of Interest Statement; Acknowledgments; References; Chapter 4 Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins; Abstract; Introduction; General Approaches to Structural Studies on Integral MPs; Illustration of Successful Structure Determination of Integral MPs; Conclusions; Acknowledgments; References
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|6 505-00/(S
|a Chapter 7 Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor OligomerisationAbstract; Trends; SpIDA: An Approach to Detect Protein Oligomerisation State; Advantages and Limitations of SpIDA for Quantification of Protein Oligomeric State; Use of SpIDA to Define the Quaternary Structure of GPCRs; Using SpIDA to Examine Potential Ligand-Induced Alterations of GPCR Quaternary Structure; Concluding Remarks; Disclaimer Statement; Acknowledgments; Glossary; References; Chapter 8 Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11
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