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Searching for a mechanism : a history of cell bioenergetics /
Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "b...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Oxford University Press,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Searching for a Mechanism; Copyright; Dedication; Contents; Preface; Acknowledgments; List of Abbreviations; 1. Introduction: Respiration, phosphorylation, and mechanism; 1.1 Respiration, photosynthesis, and bioenergetics; 1.2 Vitalism; 1.3 Historical questions; 1.4 Phosphorylation; 1.5 Mechanisms; 1.6 The relevance of cell bioenergetics to the question of mechanism; 2. From physiology to biochemistry: Respiration and oxidation from 1600 to 1900; 2.1 Initiation of the experimental study of respiration; 2.2 John Mayow's Tractatus Quinque; 2.3 Stephen Hales's Vegetable Staticks
- 2.4 Respiration and combustion2.5 The location of respiration; 2.6 Thermodynamic questions; 2.7 Bernard's criticism of slow combustion; 2.8 Hofmeister's integration of cell biology; 2.9 O2 and oxidation; 2.10 Spectroscopy, hemoglobin, and animal pigments; 2.11 Cell-free systems; 3. Relating phosphorylation, respiration, and oxidation: 1900-1945; 3.1 Resolving nineteenth-century questions; 3.2 Achievements of the first half of the twentieth century; 3.3 Yeast and animal juices: The importance of phosphate; 3.4 Thunberg, Wieland, and the nature of biological oxidation
- 3.5 Warburg's Atmungsferment3.6 Keilin's cytochrome; 3.7 DPN (NAD) and its oxidation; 3.8 Muscle, lactic acid, and energy; 3.9 Adenosine triphosphate and muscle phosphates; 3.10 Aerobic ATP synthesis: Engelhardt and Kalckar; 3.11 Phosphorylation linked to respiration: Belitzer and Ochoa; 3.12 Lipmann: The significance of phosphorylation; 4. Emergence of the field of cell bioenergetics: 1945-1960; 4.1 Emergence of a new field; 4.2 The mitochondrion as the location of respiratory activity; 4.3 Further elucidation of the respiratory chain; 4.4 Phosphorylation; 4.5 Sites for phosphorylation
- 4.6 Seeking to understand the mechanism of phosphorylation4.7 The phosphorylating enzyme; 4.8 Fragmenting mitochondria; 4.9 Physiological aspects of mitochondria; 5. Defining the mechanism: 1960-1977; 5.1 What mechanism?; 5.2 The first proton theory: Robert J. P. Williams; 5.3 The chemiosmotic hypothesis of Peter Mitchell; 5.4 Revising the respiratory chain; 5.5 Exploring the ATP synthase; 5.6 Reconstituting oxidative phosphorylation; 5.7 Bacteriorhodopsin; 5.8 Conformational theories; 5.9 Mitochondrial membranes; 5.10 Ion movements across the mitochondrial membrane
- 5.11 Resolving the mechanism6. Discovering photosynthesis; 6.1 The development of ideas on photosynthesis; 6.2 Initial studies of photosynthesis; 6.3 The importance of water and CO2; 6.4 Energy; 6.5 Discovering chlorophyll and chloroplasts; 6.6 Understanding the nature of photosynthesis; 6.7 Photosynthetic bacteria and an oxidation-reduction mechanism; 6.8 Light and dark reactions; 6.9 O2 evolution and the Hill reaction; 6.10 CO2 assimilation; 6.11 Discovering photophosphorylation; 7. Elucidating the photosynthetic light reaction; 7.1 The fourth period of photosynthetic history