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|a UAMI
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|a Lipid Rafts :
|b Properties and Role in Signaling.
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|a New York :
|b Nova Science Publishers, Incorporated,
|c 2018.
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| 300 |
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|a 1 online resource (168 pages)
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|a text
|b txt
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|a Biochemistry research trends series
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|a Print version record.
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|6 880-01
|a Intro; Contents; Preface; Chapter 1; Jak1 as the Architect for Assembling and Activating Multi-Chain Cytokine Receptor Complexes in Lipid Rafts; Abstract; Abbreviations; About Lipid Rafts; Conceptualizing Multiple Liquid Phases; The Lipid Bilayer Plasma Membrane as a 2-Dimensional Liquid; The Biophysics of Lipid Raft Domains vs. Non-Raft Domains; The Chemistry of Lipids and Lipid Rafts; Biophysical Studies: Lipid Rafts, Detergent Resistant Membranes and Synthetic Membranes; Synthetic and Reconstituted Lipid Bilayer Membranes; Endogenous Lipid Raft Detergents?; From the Research to the Model.
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|a The Biology of Lipid RaftsFRET as a Nanometer-Limited Visualization Technology; The Biological Problem Being Addressed; 1. IFN- R1 and IFN- R2 Interact Constitutively in Cells; 2. Jak1 Needed for IFN- R1 to Interact with IFN- R2, or for Other Cytokine Receptor Pairs to Interact; 3. Jak1 Needed for High Affinity between Cytokine Receptor Chains; Influence of Lipid Raft Association for Cytokine Receptor Chain Interaction; 4. Lipid Raft Association with IFN- R1 Needed for Interaction with IFN- R2; 5. Jak1 Association with IFN- R1 Necessary for High-Affinity Lipid Raft Association.
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|a 6. Only Low-Level Jak1 Associated with Membrane Correlates with Strongest IFN- R1 and IFN- R2 InteractionConclusion; References; Chapter 2; The Implication of Rafts in Atherosclerosis, Cancer or Neurodegenerative Diseases; Abstract; Introduction; Properties of Lipid Rafts; Cholesterol -- Oxysterols: Potent Modulators of Lipid Raft Formation; Role of Lipid Rafts in Signaling; Inflammation Process -- Atherogenesis; Lipid Rafts and Neurodegeneration (Marin et al., 2013); Lipid Rafts and Cancer (Zalba and Ten Hagen, 2017, Mollinedo and Gajate, 2015); Lipid Rafts and Aging; Conclusion; References.
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|a 2.1. Lipids and Other Chemicals Were Obtained as Follows2.2. Preparation of Triton-Insoluble Fraction; 2.3. Protein Preparation; 3. Results; 3.1. Triton-Insolubility of Phospholipid and the Effect of CHL; Discussion; Conclusion; Acknowledgment; Conflict of Interest; Ethical Statement; References; Index; Blank Page.
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|a Membrane lipids.
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|a Membrane Lipids
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|a Lipides membranaires.
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|a SCIENCE
|x Life Sciences
|x Biochemistry.
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|a Membrane lipids
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|a Thomas, Nils.
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|a Jonathan, Sten.
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|i Print version:
|a Thomas, Nils.
|t Lipid Rafts : Properties and Role in Signaling.
|d New York : Nova Science Publishers, Incorporated, ©2018
|z 9781536136241
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| 830 |
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|a Biochemistry research trends series.
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|z Texto completo
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|6 505-01/(S
|a Biographical SketchChapter 3; Lipid Rafts as Molecular Platforms of Neuronal Toxicity and Survival: Two Sides of the Same Coin; Abstract; 1. Introduction; 2. Lipid Rafts as Key Signaling Sites in Nerve Cells; 3. Lipid Alterations of Lipid Rafts at the Basis of Neuronal Impairment; 4. Neuronal Lipid Associations of α-Syn in Health and Disease; Conclusion; Acknowledgments; References; Biographical Sketch; Chapter 4; The Molecular Background of the Detergent-Insolubility of Neuronal Plasma Membrane; Abstract; 1. Introduction; 2. Materials and Methods.
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