Advances in organic synthesis. Volume 7 /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Rahman, Atta-ur-, 1942- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Sharjah, U.A.E : Bentham Science Publishers, 2017.
Temas:
Organic compounds > Synthesis.
Composés organiques > Synthèse.
SCIENCE > Chemistry > Organic.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • CONTENTS
  • PREFACE
  • List of Contributors
  • Small Molecules that Ameliorate Protein Mis-folding
  • Paolo Ruzza*
  • INTRODUCTION
  • Protein Folding
  • SMALL MOLECULES
  • Small Molecules that Act as Pharmacological Chaperones
  • Lipid Storage Disorders
  • Amyloid Related Diseases
  • Cystic Fibrosis
  • Small Molecules that Act as Osmolytes
  • Trehalose
  • Trimethylamine N-Oxide
  • EVALUATION OF SMALL MOLECULES EFFECTS ON PROTEIN FOLDING
  • Circular Dichroism (CD) Spectroscopy
  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • OUTLOOK
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Recent Advances in the Synthesis of Peptides and Proteins
  • Riaz A. Khan1,2,*, Mamuna Naz1, Minhajul Arfeen1 and Nahid Abbas1
  • INTRODUCTION: THE BACKGROUND, SIGNIFICANCE & PROSPECTS
  • PEPTIDES & PROTEINS: THE CHEMICAL CORE, BONDING & STRUCTURE
  • INTRICACIES IN THE FORMATION OF AN AMIDE BOND
  • COUPLING REAGENTS: ADVANCES & CONCURRENT APPROACHES
  • REACTION MEDIUM: THE ROLE IN COUPLING
  • ACTIVATION OF COUPLING REAGENTS
  • COUPLING REACTIONS
  • MONITORING OF COUPLING, AND DEBLOCKING
  • DETERMINATION OF LOAD
  • DETERMINATION OF THE EXTENT OF CLEAVAGE
  • PROTECTION STRATEGIES: PROTECTING GROUP (PG) AS THE BEGINNING OF SYNTHESIS
  • CHEMICAL SYNTHESIS OF PEPTIDES & PROTEINS: THE MAJOR STRATEGIES
  • SOLUTION PHASE SYNTHESIS (SPS): THE CLASSICAL WET CHEMISTRY
  • SOLID PHASE PEPTIDE SYNTHESIS: THE TURNING POINT & CONCURRENT ADVANCES
  • SPPS: THE COMPONENTS OF THE OPERATION & SOLID SUPPORTS' REQUIRED CHARACTERISTICS
  • CLEAVAGE FROM THE SOLID SUPPORT: THE ROLE OF LINKER
  • SYNTHESIS & USE OF A VIABLE LINKER: SPPS OF A BACTERIAL ORIGIN OCTAPEPTIDE SEQUENCE
  • APPROACHES FOR SPPS: ASPECTS OF EXPERIMENTAL METHODOLOGIES SEQUENTIAL SYNTHESIS
  • CONVERGENT SYNTHESIS
  • SYNTHETIC MODIFICATIONS OF PEPTIDES: THE STRUCTURAL DIVERSIFICATION.
  • MODIFIED PEPTIDES: PHARMACEUTICALLY ACTIVE PEPTIDIC ENTITIES
  • SYNTHESIS OF LONG-CHAIN PEPTIDES: EXAMPLES, ACCOMPLISHMENTS & CHALLENGES
  • USE OF MICROWAVE IRRADIATION IN PEPTIDE SYNTHESIS
  • THE LIGATION OF PEPTIDES: DEVELOPMENT OF NEW TECHNIQUES
  • CHEMICAL LIGATION: PROTOTYPICAL PROCESS & EXPANSION OF APPROACH
  • PREPARATION OF PEPTIDE C-TERMINAL THIOESTER BY BOC-SPPS METHOD
  • PREPARATION OF PEPTIDE C-TERMINAL THIOESTERS BY FMOC-SPPS METHOD
  • THE NATIVE CHEMICAL LIGATION (NCL) OR, TRANS-THIOESTERIFICATION
  • CYSTEINE BASED STRATEGIES FOR NCL: PREPARATION OF NON-THIOL PEPTIDES
  • APPROACH TO CYSTEINE SURROGATE: AUXILIARIES, SOLVENT, DETERGENT & SOLUBILIZING TAGS
  • PEPTIDE LIGATION WITH SULFUR: PRIOR THIOL CAPTURE FOR 'NCL'
  • ACYL-INITIATED CAPTURE: MAINTAINING 'CYS' AT LIGATION JUNCTION
  • SERINE AND THREONINE BASED LIGATIONS
  • APPROACHES WITH SELENIUM
  • CONFORMATIONALLY ASSISTED LIGATION
  • THE KAHA METHOD
  • THE STAUDINGER LIGATION
  • ONE-POT STRATEGIES FOR ASSEMBLING PEPTIDE FRAGMENTS
  • MULTIPLE SEGMENT LIGATION STRATEGIES
  • CONVENTIONAL & NON-CONVENTIONAL APPROACHES TO INVERSE SYNTHESIS: C-TO-N DIRECTION APPROACH
  • N-TO-C DIRECTION APPROACH
  • SYNTHESIS OF ACTIVATED PEPTIDES: OMER (O-MERCAPTOARYL ESTER REARRANGEMENT) APPROACH
  • PREPARATION OF THIOPEPTIDES: INTRODUCTION OF DISULFIDE LINKAGES
  • THE CYSTEINE-KNOT PEPTIDE SYNTHESIS
  • SYNTHESIS OF CYCLIC PEPTIDES
  • EXPRESSED PROTEIN LIGATION: THE BIOSYNTHESIS OF PEPTIDE FRAGMENT
  • POST-TRANSLATIONALLY MODIFIED PROTEINS
  • SYNTHESIS OF TRANSMEMBRANE (TM) PEPTIDES & PROTEINS SPECIFIC PROTOCOLS & TECHNIQUES: USE OF N-BACKBONE MODIFICATIONS
  • ADDITION OF O-ACYL ISOPEPTIDE UNIT
  • LIGATION STRATEGIES
  • SITE-SPECIFIC MANIPULATION
  • SYNTHESIS OF ISOTOPE-LABELED MEMBRANE PROTEINS
  • CHEMICAL SYNTHESIS OF PROTEINS: RECENT EXAMPLES OF BIOACTIVE SEQUENCES ERYTHROPOIETIN.
  • CHEMICAL SYNTHESIS OF INSULIN
  • PROTEIN SYNTHESIS PROTOCOLS: EXPERIMENTAL AND PROCEDURAL ASPECTS
  • FUNCTIONAL BIOCONJUGATES: JOINING PEPTIDES AND PROTEINS TOGETHER
  • FOLDING OF SYNTHETIC POLYPEPTIDES: CONFORMATIONAL ASPECTS
  • ANALYTICAL METHODS: THE CONFIRMATION OF SYNTHESIS & TERTIARY STRUCTURE
  • BULK SYNTHESIS OF PEPTIDES & PROTEINS: THE SCALE-UP
  • ENVIRONMENTAL IMPLICATIONS: THE FALL-OUT & NEEDED ADVANCEMENT(S)
  • THE SCOPE & APPLICATIONS: PEPTIDES & PROTEINS IN MEDICINAL CHEMISTRY
  • CURRENT ROLES & FUTURE PROSPECTS OF PROTEINS & PEPTIDES
  • SUMMARY
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Bioorthogonal Coupling Strategies Used in Pretargeted Nuclear Imaging and Radiotherapy
  • Justin J. Bailey1,*, Carmen Wängler2, Björn Wängler3 and Ralf Schirrmacher1
  • INTRODUCTION
  • Non-Covalent Ligation Techniques
  • Biotin/ (Strept) Avidin Coupling
  • Bispecific Antibodies/Radiolabeled Haptens Coupling
  • Chemical Ligation Techniques
  • Staudinger Ligation
  • Strain-Promoted Azide-Alkyne Cycloaddition
  • Inverse Electron Demand Diels-Alder
  • CONCLUSION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Different Concepts of Catalysis in the Synthesis of Xanthenediones: A Brief Overview
  • Milene Lopes da Silva1, Róbson Ricardo Teixeira1,* and Giovanni Wilson Amarante2
  • XANTHENEDIONES: IMPORTANCE AND SYNTHESIS
  • CATALYSTS USED IN XANTHENEDIONE SYNTHESIS
  • Lewis Acids
  • Brønsted Acid
  • Lewis and Brønsted acid
  • Organocatalysts
  • Ionic liquids
  • Nanocatalysts
  • CONCLUDING REMARKS
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Heterogeneous Catalysts in Organic Synthesis: From Nanoscale to Single Atomic Level
  • Min Li and Jingqi Guan*
  • INTRODUCTION
  • SYNTHESIS OF SINGLE ATOM CATALYST
  • Atomic Layer Deposition
  • Photochemical Technique
  • Mass-Selected Soft-Landing Strategy.
  • Chemical Reduction Method
  • Co-precipitation Method
  • Solid Melting Method
  • Galvanic Replacement Reaction Method
  • High Temperature Vapor Migration Approach
  • Cyanide Leaching Method
  • Impregnation Method
  • Organometallic Complex Method
  • Nitrogen Coordination Method
  • Pyrolysis of MOFs
  • Chemical Vapor Deposition
  • PERFORMANCE OF SINGLE ATOM CATALYSTS
  • High Activity
  • Up to 100% Atomic Utilization
  • Metal-Support Interaction
  • Unsaturated Coordination Environment
  • High Selectivity
  • High Stability
  • IDENTIFYING THE ACTIVE SITES
  • APPLICATION OF SINGLE ATOM CATALYSTS
  • CONCLUSIONS AND PERSPECTIVES
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • SUBJECT INDEX.

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