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Triple-Negative Breast Cancer.
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hauppauge :
Nova Science Publishers, Inc.,
2017.
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| Colección: | Cancer etiology, diagnosis, and treatments.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Preface; Chapter 1; The Role of Exosomes in Breast Cancer: What Have We Learned in Ten Years?; Abstract; Introduction; Exosomes: An Overview; Exosomes: In Cancer; Cancer-Associated Exosomes Containing Proteins; Cancer-Associated Exosomes Containing Nucleic Acids; miRNA-containing Exosomes; mRNA-Containing Exosomes; DNA-containing Exosomes; Cancer-Associated Exosomes Containing Lipids; Exosomes in the Breast Tumor Microenvironment; Exosomes in Hypoxia, Epithelial
- Mesenchymal Transition, ROS Production and Autophagy; Exosomes in Metastasis; Exosomes and Drug Resistance.
- Conclusion and Future PerspectivesReferences; Chapter 2; Correlations between BRCA Gene Mutations and the High Risk of TNBC as Defined by the Defect of Estrogen Signaling; Abstract; Introduction; Interplay Between Endogenous Estrogens and Wild-Type BRCA Genes; Correlations between BRCA Gene Mutations and Defective Estrogen Signaling; Decreased ER-Alpha Expression in BRCA Gene Mutation Carrier Cells; Decreased Estradiol-Liganded Transcriptional Activity of ERs in BRCA Gene Deficient Cells; Defensive Counteractions Against BRCA Gene Defects.
- Increased Aromatase Activity Associated with BRCA Gene MutationHyperestrogenism as a Compensatory Mechanism in Women with BRCA Gene Mutation; Increased Ligand-Independent Transcriptional Activity in Cells with BRCA1 Mutation; Hormonal Risk Factors for Overall Breast Cancer and TNBC; Correlations between Menopausal Status and TNBC Risk; Correlations between Reproductive History and the Risk of Different Breast Cancer Subtypes; Conclusion; References; Chapter 3; The Role of Tumor Infiltrating Lymphocytes (TILs) in Triple Negative Breast Cancer (TNBC); Abstract; Introduction.
- Pathologic and Molecular Heterogeneity of TNBCTumor-Infiltrating Lymphocytes in TNBC; a. TILs as a Prognostic Factor; b. TILs as a Predictive Factor; c. TILs as Biomarkers of Residual Disease; Targeting the Immune System in Triple-Negative Breast Cancer: Potential Role of the PD-1/PD-L1 Pathway as a Biomarker; Conclusion; References; Index; Blank Page.