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Molecular Physiology and Metabolism of the Nervous System : a Clinical Perspective.
The molecular basis for the physiology of the brain has advanced enormously in the past twenty years with an influx of new information gleaned through technological developments in neuroimaging and molecular discoveries. Molecular Physiology and Metabolism of the Nervous System, authored by Gary A....
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Oxford University Press,
©2012.
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| Colección: | Contemporary neurology series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; CONTENTS; PART 1 PHYSIOLOGY OF BRAIN FLUIDS AND THE BLOOD-BRAIN BARRIER; 1. ANATOMY OF FLUID INTERFACES THAT PROTECT THE MICROENVIRONMENT; HISTORICAL PERSPECTIVE; CEREBRAL MICROENVIRONMENT; DEVELOPMENT OF THE BRAIN-FLUID INTERFACES; EXTRACELLULAR SPACE AND EXTRACELLULAR MATRIX; BRAIN-FLUID INTERFACES; DURA, ARACHNOID, AND PIAL LAYERS; WHAT ARE THE SOURCES OF ENERGY?; 2. PHYSIOLOGY OF THE CEREBROSPINAL AND INTERSTITIAL FLUIDS; INTRODUCTION; PROTEINS IN THE CSF; CSF PRESSURE REFLECTS VENOUS PRESSURE IN THE RIGHT HEART; FORMATION, CIRCULATION, AND ABSORPTION OF CSF.
- ELECTROLYTE BALANCE IN THE CSFMENINGES AND SITES OF MASSES AND INFECTION; INTERSTITIAL FLUID; LYPHATIC DRAINAGE; WATER DIFFUSION, BULK FLOW OF ISF, AND DIFFUSION TENSOR IMAGING; NEUROPEPTIDES AND FLUID HOMEOSTASIS; AQUAPORINS AND WATER TRANSPORT IN THE CENTRAL NERVOUS SYSTEM; 3. NEUROVASCULAR UNIT; EARLY EXPERIMENTS ON THE BLOOD-BRAIN BARRIER; THE NEUROVASCULAR UNIT AND TIGHT JUNCTION PROTEINS; INTEGRINS, SELECTINS, AND ENDOTHELIAL CELL ADHESION; ASTROCYTES, PERICYTES, AND BASAL LAMINA; MOVEMENT OF SUBSTANCES INTO AND OUT OF BRAIN; GLUCOSE AND AMINO ACID TRANSPORT.
- PROTEASES AND THE NEUROVASCULAR UNITMATRIX METALLOPROTEINASES (MMPS); A DISINTEGRIN AND METALLOPROTEINASE (ADAM); BARRIER SYSTEMS EVOLVED TO AN ENDOTHELIAL BARRIER; PART 2 METABOLISM, DISORDERS OF BRAIN FLUIDS, AND MATHEMATICS OF TRANSPORT; 4. GLUCOSE, AMINO ACID, AND LIPID METABOLISM; GLUCOSE METABOLISM; AMINO ACID NEUROTRANSMITTERS; LIPID METABOLISM; EICOSANOID METABOLISM; HEPATIC ENCEPHALOPATHY; HYPOGLYCEMIA; HYPONATREMIA, OSMOTIC DEMYELINATION, AND ACID BALANCE; 5. DISORDERS OF CEREBROSPINAL CIRCULATION: IDIOPATHIC INTRACRANIAL HYPERTENSION AND HYDROCEPHALUS; INTRODUCTION.
- CLINICAL FEATURES OF IIHTREATMENT OF IIH; HYDROCEPHALUS; HYDROCEPHALUS IN CHILDREN; ADULT-ONSET HYDROCEPHALUS; 6. QUANTIFICATION OF CEREBRAL BLOOD FLOW AND BLOOD-BRAIN BARRIER TRANSPORT BY NUCLEAR MAGNETIC RESONANCE AND POSITRON EMISSION TOMOGRAPHY; INTRODUCTION; MATHEMATICAL APPROACH TO CBF AND TRANSPORT; POSITRON EMISSION TOMOGRAPHY; MRI IN CBF AND TRANSPORT MEASUREMENT; MRI AND SPECTROSCOPY; PART 3 ISCHEMIA, EDEMA, AND INFLAMMATION; 7. MECHANISMS OF ISCHEMIC/HYPOXIC BRAIN INJURY; EPIDEMIOLOGY, RISK FACTORS, AND PREVENTION OF STROKE.
- MOLECULAR CASCADES IN ISCHEMIC TISSUE RESULTS FROM ENERGY FAILUREEXCITATORY AND INHIBITORY NEUROTRANSMITTERS; NEUROINFLAMMATION IN STROKE; PROTEASES IN HYPOXIA/ISCHEMIA; CASPASES AND CELL DEATH; TISSUE INHIBITORS OF METALLOPROTEINASES AND APOPTOSIS; TIGHT JUNCTION PROTEINS AND MMPS; MMPS AND TPA-INDUCED BLEEDING; ANIMAL MODELS IN STROKE; ARTERIOVENOUS MALFORMATIONS AND CAVERNOUS HEMANGIOMAS; MAGNETIC RESONANCE IMAGING, POSITRON EMISSION TOMOGRAPHY, AND ELECTRON PARAMAGNETIC RESONANCE IN HYPOXIA/ISCHEMIA; 8. VASCULAR COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE.