Cargando…
Life histories of genetic disease : patterns and prevention in postwar medical genetics /
Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today's expecting parents to choose to test pren...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Baltimore :
Johns Hopkins University Press,
2016.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 i 4500 | ||
|---|---|---|---|
| 001 | EBSCO_ocn959618062 | ||
| 003 | OCoLC | ||
| 005 | 20231017213018.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 160930s2016 mdu ob 001 0 eng d | ||
| 040 | |a N$T |b eng |e rda |e pn |c N$T |d YDX |d EBLCP |d N$T |d MUB |d OCLCO |d P@U |d OCLCO |d OCLCF |d OCLCA |d NJR |d OCLCQ |d SNK |d DKU |d AUW |d INTCL |d MHW |d IGB |d D6H |d STF |d WRM |d VTS |d EZ9 |d AGLDB |d JBG |d AU@ |d WYU |d OCLCQ |d OCLCO |d G3B |d OCLCO |d LVT |d S8J |d S9I |d OCLCQ |d OCLCO |d OCLCA |d UKAHL |d OCLCQ |d OCLCO |d OCLCQ | ||
| 019 | |a 959910022 |a 962055532 |a 963359569 |a 964540412 |a 964932936 | ||
| 020 | |a 9781421420752 |q (electronic bk.) | ||
| 020 | |a 1421420759 |q (electronic bk.) | ||
| 020 | |z 9781421420745 | ||
| 020 | |z 1421420740 | ||
| 029 | 1 | |a AU@ |b 000058946964 | |
| 035 | |a (OCoLC)959618062 |z (OCoLC)959910022 |z (OCoLC)962055532 |z (OCoLC)963359569 |z (OCoLC)964540412 |z (OCoLC)964932936 | ||
| 050 | 4 | |a RB155 | |
| 060 | 4 | |a QZ 11.1 | |
| 072 | 7 | |a HEA |x 039000 |2 bisacsh | |
| 072 | 7 | |a MED |x 014000 |2 bisacsh | |
| 072 | 7 | |a MED |x 022000 |2 bisacsh | |
| 072 | 7 | |a MED |x 112000 |2 bisacsh | |
| 072 | 7 | |a MED |x 045000 |2 bisacsh | |
| 082 | 0 | 4 | |a 616/.042 |2 23 |
| 049 | |a UAMI | ||
| 100 | 1 | |a Hogan, Andrew J., |e author. | |
| 245 | 1 | 0 | |a Life histories of genetic disease : |b patterns and prevention in postwar medical genetics / |c Andrew J. Hogan. |
| 264 | 1 | |a Baltimore : |b Johns Hopkins University Press, |c 2016. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a data file | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Introduction : pursuing a better birth -- Genetics detectives -- Chromosomal cartography -- The genome's morbid anatomy -- Seeing with molecules -- Institutionalized disorders -- Getting the whole picture -- Epilogue : the genomic gaze. | |
| 520 | 8 | |a Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today's expecting parents to choose to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In Life Histories of Genetic Disease, Andrew J. Hogan explores how various diseases were "made genetic" after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger-and increasingly "big data"--Oriented-aims of biomedical research | |
| 588 | 0 | |a Print version record. | |
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 650 | 0 | |a Medical genetics. | |
| 650 | 0 | |a Medical genetics |x Moral and ethical aspects. | |
| 650 | 0 | |a Genetic disorders |x Diagnosis. | |
| 650 | 1 | 2 | |a Genetics, Medical |x history |
| 650 | 1 | 2 | |a Genetic Diseases, Inborn |x prevention & control |
| 650 | 2 | |a Genetics, Medical | |
| 650 | 2 | 2 | |a History, 21st Century |
| 650 | 2 | 2 | |a History, 20th Century |
| 650 | 6 | |a Génétique médicale. | |
| 650 | 6 | |a Génétique médicale |x Aspect moral. | |
| 650 | 6 | |a Maladies génétiques |x Diagnostic. | |
| 650 | 6 | |a Médecine |x Histoire |y 21e siècle. | |
| 650 | 6 | |a Médecine |x Histoire |y 20e siècle. | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Diseases. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Genetic disorders |x Diagnosis. |2 fast |0 (OCoLC)fst00940011 | |
| 650 | 7 | |a Medical genetics. |2 fast |0 (OCoLC)fst01014133 | |
| 650 | 7 | |a Medical genetics |x Moral and ethical aspects. |2 fast |0 (OCoLC)fst01014139 | |
| 776 | 0 | 8 | |i Print version: |a Hogan, Andrew J. |t Life histories of genetic disease. |d Baltimore : Johns Hopkins University Press, 2016 |z 9781421420745 |w (DLC) 2015050732 |w (OCoLC)934019893 |
| 856 | 4 | 0 | |u https://ebsco.uam.elogim.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1220060 |z Texto completo |
| 938 | |a Askews and Holts Library Services |b ASKH |n AH35310184 | ||
| 938 | |a ProQuest Ebook Central |b EBLB |n EBL7028974 | ||
| 938 | |a ProQuest Ebook Central |b EBLB |n EBL4531451 | ||
| 938 | |a EBSCOhost |b EBSC |n 1220060 | ||
| 938 | |a Project MUSE |b MUSE |n muse53201 | ||
| 938 | |a YBP Library Services |b YANK |n 13196378 | ||
| 994 | |a 92 |b IZTAP | ||