G-quadruplex structures : formation and role in biology /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Santos, Hannah (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Science Publishers, 2016.
Colección:Biochemistry research trends series.
Temas:
Quadruplex nucleic acids.
Nucleic acids.
Nucleic Acids
Acides nucléiques.
SCIENCE / Life Sciences / Biochemistry
Acceso en línea:Texto completo
Tabla de Contenidos:
  • G-QUADRUPLEX STRUCTURES, FORMATION AND ROLE IN BIOLOGY; G-QUADRUPLEX STRUCTURES, FORMATION AND ROLE IN BIOLOGY; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: DESIGNING G-QUADRUPLEX TOPOLOGIES BY FOCUSING ON SEQUENCE MODIFICATIONS; ABSTRACT; INTRODUCTION; 1. EFFECT OF SEQUENCE ON QUADRUPLEX TOPOLOGY; 1.1. G-rich Sequences That Predispose Majority Folds; 1.2. Effects of Sequence and Length of the Loops on Folding Topology; 2. MUTATIONS OF SEQUENCES BY NATURAL AND SYNTHETIC NUCLEOTIDES THAT STABILIZE SINGLE FOLDS; 2.1. Guanine Analogs in the G-tetrads
  • 2.2. Sugar Analogs of Tetrad Guanosines2.3. Modification of the Sugar-Phosphate Backbone; 2.4. Loops with Nucleotide Analogs; 2.5. Topologically Constrained Quadruplexes; 3. EFFECT OF CATION AND ITS CONCENTRATION ON G-QUADRUPLEX FOLDING; 4. TOPOLOGY CHANGES IN MOLECULAR CROWDING
  • EFFECT OF COSOLUTES; 5. EFFECT OF HIGH DNA CONCENTRATIONS ON THE FOLDING TOPOLOGY OF QUADRUPLEXES; CONCLUSION; REFERENCES; Chapter 2: G-QUADRUPLEXES AND I-MOTIFS AS SCAFFOLDS FOR MOLECULAR ENGINEERING OF DNA APTAMERS; ABSTRACT; APTAMERS AS A CLASS OF MOLECULAR RECOGNITION ELEMENTS; HD1, A KEY DNA APTAMER TO THROMBIN
  • ALTERING THE SEQUENCE OF HD1Altering Guanines of G-Quartets; Altering the TGT-Loop; Altering TT-Loops; ALTERING THE CONFORMATION OF HD1 WITH CATIONS; MODULATING THE ACTIVITY OF THROMBIN APTAMER WITH ADDITIONAL DUPLEX ELEMENT; MODULATING THE ACTIVITY OF THROMBIN APTAMER WITH ADDITIONAL G-QUADRUPLEX ELEMENT; SELECTIVITY OF THROMBIN APTAMERS TOWARD THROMBIN-RELATED PROTEINS; APTAMERS TO HEMAGGLUTININ WITH I-MOTIFS; CONCLUSION; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 3: DOUBLE HELICES FORMING UNUSUAL BINDING MOTIFS: THE CASE OF THE NATURAL ALKALOIDS COPTISINE AND CHELERYTHRINE; ABSTRACT
  • INTRODUCTIONMATERIAL AND METHODS; Crystallization Experiments; X-ray Diffraction Analyses; QM and QM/MM Calculations; RESULTS; DISCUSSION; CONCLUSION; FUNDING; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 4: G-QUADRUPLEX-INDUCED FLUORESCENCE SIGNAL; ABSTRACT; INTRODUCTION; Fluorescent Probes for G-Quadruplexes; NONCOVALENT PROBES FOR G-QUADRUPLEXES; Fluorescent Intercalator Displacement; FRET; Small Molecules; Cyanine Dyes; V-Shaped Planer Molecule; Metal Complexes; Thioflavin T; Triphenylmethane Dyes; Carbazole Derivatives; Aggregation-Induced Emission; Porphyrin Derivatives
  • COVALENT PROBES FOR G-QUADRUPLEXESCONCLUSION AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 5: G-QUADRUPLEX INTERACTING SMALL MOLECULES AND THEIR BIOLOGICAL IIMPLICATIONS; ABSTRACT; INTRODUCTION; STUDYING G-QUADRUPLEX BIOLOGY WITH SMALL MOLECULES; TELOMERE MAINTENANCE AND THE DNA DAMAGE RESPONSE; GENE TRANSCRIPTION AND TRANSLATION; GENOMIC CONTROL MECHANISMS; G-QUADRUPLEX INTERACTING SMALL MOLECULES AND CLINICAL APPLICATIONS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 6: ASSAYS FOR TELOMERASE ACTIVITY TOWARD APPLICATIONS OF CANCER DIAGNOSIS ; ABSTRACT

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