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160711s2016 nyu o 001 0 eng |
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|a 2016031885
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|a 959031679
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|a 9781634855501
|q (ebook)
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|a 1634855507
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|z 9781634855129 (hardcover)
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|z 1634855124
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|b 000057887171
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|z (OCoLC)959031679
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|a 572.8/5
|2 23
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|a UAMI
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| 245 |
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|a G-quadruplex structures :
|b formation and role in biology /
|c Hannah Santos, editor.
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| 264 |
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|a New York :
|b Nova Science Publishers,
|c 2016.
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| 300 |
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|a 1 online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b n
|2 rdamedia
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| 338 |
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|a online resource
|b nc
|2 rdacarrier
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| 490 |
1 |
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|a Biochemistry research trends
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| 500 |
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|a Includes index.
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| 588 |
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|a Description based on print version record and CIP data provided by publisher; resource not viewed.
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|a G-QUADRUPLEX STRUCTURES, FORMATION AND ROLE IN BIOLOGY; G-QUADRUPLEX STRUCTURES, FORMATION AND ROLE IN BIOLOGY; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: DESIGNING G-QUADRUPLEX TOPOLOGIES BY FOCUSING ON SEQUENCE MODIFICATIONS; ABSTRACT; INTRODUCTION; 1. EFFECT OF SEQUENCE ON QUADRUPLEX TOPOLOGY; 1.1. G-rich Sequences That Predispose Majority Folds; 1.2. Effects of Sequence and Length of the Loops on Folding Topology; 2. MUTATIONS OF SEQUENCES BY NATURAL AND SYNTHETIC NUCLEOTIDES THAT STABILIZE SINGLE FOLDS; 2.1. Guanine Analogs in the G-tetrads
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|a 2.2. Sugar Analogs of Tetrad Guanosines2.3. Modification of the Sugar-Phosphate Backbone; 2.4. Loops with Nucleotide Analogs; 2.5. Topologically Constrained Quadruplexes; 3. EFFECT OF CATION AND ITS CONCENTRATION ON G-QUADRUPLEX FOLDING; 4. TOPOLOGY CHANGES IN MOLECULAR CROWDING -- EFFECT OF COSOLUTES; 5. EFFECT OF HIGH DNA CONCENTRATIONS ON THE FOLDING TOPOLOGY OF QUADRUPLEXES; CONCLUSION; REFERENCES; Chapter 2: G-QUADRUPLEXES AND I-MOTIFS AS SCAFFOLDS FOR MOLECULAR ENGINEERING OF DNA APTAMERS; ABSTRACT; APTAMERS AS A CLASS OF MOLECULAR RECOGNITION ELEMENTS; HD1, A KEY DNA APTAMER TO THROMBIN
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|a ALTERING THE SEQUENCE OF HD1Altering Guanines of G-Quartets; Altering the TGT-Loop; Altering TT-Loops; ALTERING THE CONFORMATION OF HD1 WITH CATIONS; MODULATING THE ACTIVITY OF THROMBIN APTAMER WITH ADDITIONAL DUPLEX ELEMENT; MODULATING THE ACTIVITY OF THROMBIN APTAMER WITH ADDITIONAL G-QUADRUPLEX ELEMENT; SELECTIVITY OF THROMBIN APTAMERS TOWARD THROMBIN-RELATED PROTEINS; APTAMERS TO HEMAGGLUTININ WITH I-MOTIFS; CONCLUSION; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 3: DOUBLE HELICES FORMING UNUSUAL BINDING MOTIFS: THE CASE OF THE NATURAL ALKALOIDS COPTISINE AND CHELERYTHRINE; ABSTRACT
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|a INTRODUCTIONMATERIAL AND METHODS; Crystallization Experiments; X-ray Diffraction Analyses; QM and QM/MM Calculations; RESULTS; DISCUSSION; CONCLUSION; FUNDING; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 4: G-QUADRUPLEX-INDUCED FLUORESCENCE SIGNAL; ABSTRACT; INTRODUCTION; Fluorescent Probes for G-Quadruplexes; NONCOVALENT PROBES FOR G-QUADRUPLEXES; Fluorescent Intercalator Displacement; FRET; Small Molecules; Cyanine Dyes; V-Shaped Planer Molecule; Metal Complexes; Thioflavin T; Triphenylmethane Dyes; Carbazole Derivatives; Aggregation-Induced Emission; Porphyrin Derivatives
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|a COVALENT PROBES FOR G-QUADRUPLEXESCONCLUSION AND PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 5: G-QUADRUPLEX INTERACTING SMALL MOLECULES AND THEIR BIOLOGICAL IIMPLICATIONS; ABSTRACT; INTRODUCTION; STUDYING G-QUADRUPLEX BIOLOGY WITH SMALL MOLECULES; TELOMERE MAINTENANCE AND THE DNA DAMAGE RESPONSE; GENE TRANSCRIPTION AND TRANSLATION; GENOMIC CONTROL MECHANISMS; G-QUADRUPLEX INTERACTING SMALL MOLECULES AND CLINICAL APPLICATIONS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; BIOGRAPHICAL SKETCH; Chapter 6: ASSAYS FOR TELOMERASE ACTIVITY TOWARD APPLICATIONS OF CANCER DIAGNOSIS ; ABSTRACT
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| 590 |
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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| 650 |
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|a Quadruplex nucleic acids.
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| 650 |
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|a Nucleic acids.
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| 650 |
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2 |
|a Nucleic Acids
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| 650 |
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|a Acides nucléiques.
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| 650 |
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|a SCIENCE / Life Sciences / Biochemistry
|2 bisacsh
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| 650 |
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|a Nucleic acids.
|2 fast
|0 (OCoLC)fst01041070
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| 650 |
|
7 |
|a Quadruplex nucleic acids.
|2 fast
|0 (OCoLC)fst01742566
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| 700 |
1 |
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|a Santos, Hannah,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t G-quadruplex structures
|d Hauppauge, New York : Nova Science Publishers, Inc., 2016
|z 9781634855129
|w (DLC) 2016023906
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| 830 |
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0 |
|a Biochemistry research trends series.
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| 856 |
4 |
0 |
|u https://ebsco.uam.elogim.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1345697
|z Texto completo
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