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Aluminum neurotoxicity : from subtle molecular lesions to neurological diseases /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Biomedical,
2016.
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| Colección: | Neurology--laboratory and clinical research development series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ALUMINUM NEUROTOXICITY FROM SUBTLE MOLECULAR LESIONS TO NEUROLOGICAL DISEASES ; ALUMINUM NEUROTOXICITY FROM SUBTLE MOLECULAR LESIONS TO NEUROLOGICAL DISEASES ; CONTENTS ; PREFACE; Chapter 1 MECHANISTIC ASPECTS OF ALUMINIUM NEUROTOXICITY: OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTIONS ; ABSTRACT ; INTRODUCTION ; NEUROTOXICITY OF ALUMINIUM ; Oxidative Stress in Aluminium Neurotoxicity ; Mitochondrial Oxidative Stress and Dysfunction in Aluminium Neurotoxicity ; Impaired Mitochondrial Energy Metabolism and Oxidative Phosphorylation ; Dysregulated Calcium (Ca2+) Homeostasis
- Mitochondria Mediated Apoptosis in Aluminum Neurotoxicity CONCLUSION; REFERENCES ; Chapter 2 ALUMINIUM AND IMBALANCE IN NEUROTRANSMITTER RELEASE ; ABSTRACT ; ABBREVIATIONS; INTRODUCTION ; ALUMINIUM-RELATED NEUROPATHIES ; ALUMINIUM INTERFERES WITH GASEOUS NEUROTRANSMISSION ; Aluminium and H2S Signalling ; Aluminium and CO Synthesis; Aluminium and Nitroxidergic Neurons ; REVERSAL OF PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORTERS IS DYSREGULATED BY ALUMINIUM ; Aluminium and Neurotransmitter Transporters ; Aluminium Effect on Sodium-Dependent Transport of Neurotransmitters
- Aluminium Effect on Modulators of Neurotransmitter Transporters Aluminium Effect on Na/K-ATPase and Neurotransmitter Release ; ALUMINIUM REDUCES SNARE-MEDIATED, CALCIUM-DEPENDENT EXOCYTOSIS ; Aluminium Effect on Presynaptic Calcium and Neurosecretion ; Aluminium and the Fusion Pore Properties ; CONCLUSION ; REFERENCES ; Chapter 3 THE RISK OF ALUMINIUM NEUROTOXICITY FOR YOUNG ANIMALS AND HUMANS DUE TO MULTIPLE EXPOSURE OPPORTUNITIES, PARTICULARLY PERINATAL ; ABSTRACT ; INTRODUCTION ; MATERIALS AND METHODS ; Animals ; Experimental Design for Al Treatments
- Physical Assessment during Weaning Period Body Weight ; Eye Opening and Hair Appearance ; Neuromotor Maturation Assessment during Weaning Period ; Righting Reflex ; Cliff Avoidance ; Rotating Reflex ; Cognitive Behavioral Assessment ; Active Avoidance Responses ; Morris Water-Maze Test ; Biochemical Studies ; Determination of Monoamines ; Determination of Nonenzymatic OS Indices ; Lipid Peroxides ; Glutathione ; Determination of Enzymatic OS Indices ; Glutathione-S-Transferase ; Catalase ; Superoxide Dismutase ; Statistical Analysis ; RESULTS ; Physical Assessment during Weaning Period
- Behavioral Studies Neuromotor Maturation ; Active Avoidance Test ; Morris Water-Maze Task ; Biochemical Studies ; Levels of Monoamines in Forebrain ; Levels of Nonenzymatic OS Indices ; Levels of Enzymatic OS Indices ; DISCUSSION ; CONCLUSION ; ACKNOWLEDGMENT ; REFERENCES; Chapter 4 THE PROTECTIVE AND DOSE-DEPENDENT EFFECTS OF L-NAME IN ALUMINIUM-INDUCED NEUROTOXICITY ; ABSTRACT ; ABBREVIATIONS; INTRODUCTION; NITRIC OXIDE ; Nitric Oxide Synthesis ; Nitric Oxide Actions ; NITRIC OXIDE: MITOCHONDRIA AND GLYCOLYSIS ; THE REACTIVE NITROGEN SPECIES AND NITROSATIVE STRESS