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Endoplasmic reticulum stress : regulation, function and role in health and disease /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Science Publisher's,
[2016]
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| Colección: | Cell biology research progress.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ENDOPLASMIC RETICULUM STRESS: REGULATION, FUNCTION AND ROLE IN HEALTH AND DISEASE; ENDOPLASMIC RETICULUM STRESS: REGULATION, FUNCTION AND ROLE IN HEALTH AND DISEASE; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; Chapter 1: POTENTIAL ROLE OF ENDOPLASMIC RETICULUM STRESS ACTIVATION IN OBESITY AND TYPE 2 DIABETES PATHOPHYSIOLOGY; ABSTRACT; 1. INTRODUCTION; 2. LIPOTOXICITY: WHEN LIPIDS CAUSE HOMEOSTATICFAILURE DURING OBESITY; 2.1. Lipotoxicity: Lipidic Inducers of ER Stress; 2.1.1. Ceramides; 2.1.2. Free Fatty Acids (FFA) and Diacylglycerol (DAG)
- 3. ER STRESS, A RESPONSE TO RECOVER CELLHOMEOSTASIS OR THE ONSET OF ITS DISRUPTION?3.1. Molecular Transducers during ER Stress Activation; 3.2. ER Stress Activation and Inflammation during Obesity; 3.3. Tissue Specific Activation of ER Stress during Obesity; 3.3.1. Adipose Tissue; 3.3.2. Skeletal Muscle; 3.3.3. Liver; 3.3.4. Hypothalamus; 4. MITOCHONDRIAL DYSFUNCTION, OXIDATIVE STRESSAND ER CALCIUM RELEASE; 5. MITOCHONDRIA ASSOCIATED MEMBRANES (MAMS):CROSSTALK BETWEEN ER AND MITOCHONDRIA
- 6. MODULATION OF ER STRESS AND MAMS:A POTENTIAL TARGET TO REVERT METABOLICABNORMALITIES ASSOCIATED TO OBESITYCONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: SIGNALING PATHWAYS PROMOTING BETA CELL SURVIVAL UNDER ER STRESS: ROLE OF SPHINGOSINE 1-PHOSPHATE AND CELLULAR INHIBITOR OF APOPTOSIS PROTEIN-1; ABSTRACT; INTRODUCTION; ER STRESS IN THE BALANCE BETWEENBETA CELL DEATH AND SURVIVAL; ROLE OF THE UPR IN BETA CELL SURVIVAL; ROLE OF THE UPR IN BETA CELL APOPTOSIS; ER STRESS IN BETA CELL FAILURE; THE ROLE OF CIAP1 IN BETA CELL SURVIVALUNDER ER STRESS
- THE ROLE OF S1P IN BETA CELL SURVIVALUNDER ER STRESSCONCLUSION; REFERENCES; Chapter 3: DIET-DERIVED INTEGRATED STRESS RESPONSES, EIF2A KINASE, AND RELATED DISEASES; ABSTRACT; 1. HIGH FAT DIET AND GUT BARRIER DISRUPTION BYFOODBORNE INSULTS TRIGGER ENDOPLASMICRETICULUM (ER) STRESS RESPONSE IN OBESITYAND INFLAMMATION; 2. AMINO ACID DEFICIENCY, GUT MICROBIALRECOGNITION, AND IMMUNOREGULATORYSIGNALS VIA GCN2; 3. DIETARY IRON METABOLISM AND INFLAMMATORYSTRESS VIA HRI; 4. FOOD CONTAMINANT-INDUCED RIBOSOMALINACTIVATION AND ISR; 5. DIETARY FACTOR-MEDIATED INTERVENTIONWITH ISR AND DISEASE PREVENTION
- ACKNOWLEDGMENTSREFERENCES; Chapter 4: PLACENTAL ENDOPLASMIC RETICULUM STRESS IN THE DETERMINATION OF PREGNANCY OUTCOME: FROM HOMEOSTASIS TO PATHOPHYSIOLOGY; ABSTRACT; INTRODUCTION; ROLE OF THE PLACENTA IN PREGNANCY; TROPHOBLAST INVASION AND ARTERIAL REMODELING; DETECTIVE PLACENTATION ANDPLACENTAL OXIDATIVE STRESS; FUNCTIONS OF ENDOPLASMIC RETICULUM; UNFOLDED PROTEIN RESPONSE; THE HOMEOSTATIC ROLE OF UPR SIGNALING; THE ROLE OF UPR SIGNALING IN PATHOLOGY; ENDOPLASMIC RETICULUM STRESS IN COMPLICATIONSOF HUMAN PREGNANCY; Evidence of ER Stress in Placenta and Deciduaof Complicated Pregnancies