Nanoparticles : preparation and characterization /

Nanotechnology and nanoparticles have emerged as an important tool towards improving cancer therapeutics and diagnostics. Recognizing the indispensable role of nanoparticles specifically in targeted delivery of chemotherapeutic and other anti-cancer agents to tumors, this book provides a comprehensi...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Pande, Maneesha (Autor), Bhaskarwar, Ashok N. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York [New York] (222 East 46th Street, New York, NY 10017) : Momentum Press, 2016.
Colección:Nanotechnology collection.
Temas:
Nanoparticles.
Nanoparticles
Nanoparticules.
microscopy
nanoparticle characterization
nanoparticle preparation methods
nanoparticle toxicity
nanoparticles
nanotechnology
targeted drug delivery
tumor
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Introduction to nanotechnology
  • 1.1 Nanotechnology: definition
  • 1.2 Nanomedicine.
  • 2. Nanotechnology in cancer diagnostics, therapeutics, and imaging
  • 2.1 Genesis of cancer
  • 2.1.1 Causes of mutation
  • 2.1.2 Characteristics of cancer cells
  • 2.1.3 Growth of a tumor
  • 2.2 Cancer diagnostics
  • 2.3 Cancer imaging
  • 2.3.1 Molecular imaging
  • 2.3.2 Role of nanoparticles in cancer diagnostics and imaging
  • 2.3.3 Quantum dots in cancer imaging
  • 2.4 Cancer therapeutics
  • 2.4.1 Cancer targeting
  • 2.4.2 Role of nanoparticles in cancer therapeutics.
  • 3. Methods of preparation of nanoparticles for drug delivery
  • 3.1 Theoretical considerations behind formation of nanoparticles
  • 3.1.1 Phase equilibria: fundamental considerations
  • 3.2 Methods based on nanoprecipitation from single phase systems
  • 3.2.1 Precipitation/co-precipitation
  • 3.2.2 Microemulsion method
  • 3.2.3 Solvent displacement method
  • 3.3 Methods based on formation of nanoparticles from heterogenous systems: emulsion based processes
  • 3.3.1 Methods based on homogenization
  • 3.3.2 Methods based on the formation of nanoparticles from preformed polymers
  • 3.3.3 Methods based on polymerization from monomers
  • 3.4 Methods based on complexation by electrostatic/ionic interactions
  • 3.4.1 Methods based on formation of polyelectrolyte complex
  • 3.4.2 Methods based on ionic crosslinking (Ionotropic gelation)
  • 3.5 Nanoparticles produced by desolvation of macromolecules
  • 3.6 Techniques based on supercritical or compressed fluids
  • 3.6.1 Hydrothermal methods
  • 3.7 Sonochemical methods
  • 3.8 Microwave assisted methods
  • 3.9 Separation of nanoparticles
  • 3.9.1 Ultracentrifugation followed by lyophilization
  • 3.9.2 Magnetic separation methods
  • 3.9.3 Membrane filtration
  • 3.9.4 Calcination.
  • 4. Characterization of nanoparticles
  • 4.1 Methods based on microscopy
  • 4.1.1 Electron microscopy
  • 4.1.2 Scanning tunneling microscopy
  • 4.1.3 Atomic force microscopy
  • 4.2 Methods based on scattering of light
  • 4.2.1 Dynamic light scattering
  • 4.2.2 Static light scattering
  • 4.2.3 Scattering tracking analysis
  • 4.2.4 Small angle x-ray scattering.
  • 5. Toxicity of nanoparticles
  • 5.1 In vivo toxicity
  • 5.1.1 Effect of nanoparticles on the respiratory system
  • 5.1.2 Effect of nanoparticles on the cardiovascular system
  • 5.1.3 Effect of nanoparticles on skin
  • 5.1.4 Effect of nanoparticles on the gastrointestinal tract
  • 5.1.5 Effect of nanoparticles on the reproductive system
  • 5.1.6 Effect of nanoparticles on the immune system
  • 5.1.7 Effect of nanoparticles on neurological system: brain and the blood-brain barrier
  • 5.1.8 Nanoparticles and genotoxicity
  • 5.2 Mechanisms of in vivo toxicity of nanoparticles
  • 5.2.1 Generation of reactive oxygen species
  • 5.2.2 Frustrated phagocytosis
  • 5.3 Ecotoxicity of nanoparticles.
  • 6. Current status and future scope
  • 6.1 Cancer theranostics
  • 6.2 Cell derived nanoparticles
  • 6.3 Upconverting nanoparticles
  • 6.4 Need for regulation
  • References
  • Index.

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