Epigenetics : mechanisms and clinical perspectives /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Dincer, Yildiz (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical, [2016]
Colección:Genetics--research and issues series.
Temas:
Epigenetics.
Genetic regulation.
Epigenomics
Gene Expression Regulation
Épigénétique.
Régulation génétique.
SCIENCE > Life Sciences > Biochemistry.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; CONTENTS; PREFACE ; Chapter 1 EPIGENETIC MODIFICATIONS AND DEVELOPMENTAL ORIGIN OF HEALTH AND DISEASES (DOHAD) ; Abstract; Abbreviations; 1. Introduction; 2. What Is Epigenetics?; 2.1. DNA Methylation; 2.2. MicroRNAs; 3. Evidence from Human Cohorts; 3.1. Fetal Programming Hypothesis; 3.2. DNA Methylation and Fetal Programming Hypothesis; 3.3. MicroRNAs and Fetal Programming Hypothesis; 4. Evidence from Animal Experiments; 4.1. DNA Methylation and Animal Experiments
  • 4.1.1. Maternal Nutrition4.1.2. Paternal Nutrition; 4.2. MicroRNAs and Animal Experiments; 4.2.1. Maternal Nutrition; 4.2.2. Paternal Nutrition; 5. Developmental Plasticity and Reversibility; Conclusion and Further Perspective; References; Chapter 2 EFFECTS OF OXIDATIVE STRESS ON EPIGENETIC MECHANISMS ; Abstract; Abbreviations; 1. Epigenetic Mechanisms; 1.1. DNA Methylation; 1.2. Histone Post-translational Modifications; 1.3. Micro RNAs and Epigenetic; 2. Oxidative Stress; 3. Interactions between Oxidative Stress and Epigenetic Mechanisms; 3.1. Oxidative Stress
  • DNA Methylation
  • 3.2. Oxidative Stress
  • Histone Post-Translational Modifications3.3. Oxidative Stress
  • miRNAs; Conclusion; References; Chapter 3 EPIGENETIC MODIFICATIONS AND THEIR POTENTIAL ROLE IN TUMORIGENESIS ; Abstract; Abbreviations; 1. Introduction; 2. The Dysregulation of Epigenetic Factors in Various Cancers; 2.1. The Deregulation of DNA Methylation in Cancer; 2.2. The Deregulation of Histone Lysine Methylation in Cancer; 2.3. The Deregulation of Histone Lysine Demethylases in Cancer; 3. Histone Lysine Acetylation in Cancer
  • 3.1. The Deregulation of Histone Lysine Acetyltransferases in Tumor Proliferation and Metastasis3.2. The Deregulation of Histone Lysine Deacetylases (KDACs) in Cancer; 4. Histone Acetylation "Code" as a Diagnostic Marker for Cancer Progression; 5. Epigenetic Modifications in Oncogenes and Tumor Suppressor Genes; 6. Epigenetic Modifications in Cellular Signaling Pathways; 6.1. NF-(B Signaling Pathway; 6.2. STAT3 Signaling Cascade; 6.3. Wnt/(-Catenin Signaling Pathway; 7. Epigenetic Modification in Cancer Stem Cells

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