Mechanical blood trauma in circulatory-assist devices /

Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses -...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Maul, Timothy M. (Timothy Michael) (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : ASME Press, [2015]
Temas:
Congestive heart failure > Treatment.
Blood > Circulation, Artificial.
Cardiovascular instruments, Implanted.
Cardiopulmonary bypass.
Extracorporeal Circulation
Cardiopulmonary Bypass
Insuffisance cardiaque globale > Traitement.
Circulation extracorporelle.
Appareils cardiovasculaires implantés.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Introduction.
  • 2. Hemolysis.
  • 3. Testing blood trauma in circulatory assist devices
  • 3.1 Historical overview
  • 3.2 Mechanical stresses which produce high levels of hemolysis.
  • 4. Sublethal blood trauma
  • 4.1 Effect of mechanical stress on RBC deformability
  • 4.2 Effect of mechanical stress on RBC aggregation
  • 4.3 Mechanical fragility of red blood cells.
  • 5. Damage to leukocytes
  • 5.1 Thrombosis and bleeding
  • 5.1.1 In vitro studies of the mechanical stress effects on platelets.
  • 6. In vitro testing devices for blood biocompatibility
  • 6.1 Methods of plasma free Hb measurement
  • 6.1.1 OxyHb absorbency at 540 nm
  • 6.1.2 Cripps method
  • 6.2 Normalized Index of Hemolysis.
  • 7. Clinical issues and experience
  • 7.1 Sequelae from hemolysis
  • 7.2 Hemoglobin-haptoglobin complex
  • 7.3 Effect of free Hb on platelets
  • 7.4 Historical review of devices and resultant hemolysis issues
  • 7.5 Surgical approaches to limit hemolysis.
  • 8. Medical therapy elevated plasma free hemoglobin.
  • 9. Concluding remarks.
  • 10. References.

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