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Polyphosphazenes for medical applications /
Polyphosphazenes are a unique family of inorganic polymers with an unparalleled broad spectrum. of properties. Furthermore, these properties can be easily fine-tuned by organic side-group substituents to give poly(organo)phosphazenes with precisely desired characteristics making them valuable tools...
| Clasificación: | Libro Electrónico |
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| Autores principales: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Shrewsbury, Shropshire, UK :
Smithers Rapra,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Preface; 1 Synthetic Procedures; 1.1 Poly(dichloro)phosphazene; 1.2 Macromolecular Substitution; 1.3 Ring-opening Polymerisation; 1.4 Chain Growth Polycondensation; 1.5 Macromolecular Architecture; 1.5.1 P-N Backbone Branching; 1.5.2 Grafting; 1.5.3 Block Copolymers; 1.5.4 Self-assembly; 1.6 Conclusion; References; 2 Degradable Poly(organo) phosphazenes; 2.1 Bioerodible Polymers for Biomedicine; 2.1.1 Bioerodible Solid Biomaterials and Polymer Matrices; 2.1.2 Water-soluble, Degradable Polymers; 2.2 Poly(organo)phosphazene Degradation.
- 2.2.1 Side-group Influence on Degradation Kinetics2.2.2 Amino Acid Ester-derived Polyphosphazenes; 2.2.3 The Effect of pH; 2.3 Degradable Molecular-level Hybrids; 2.4 Blends of Poly(organo)phosphazenes; 2.5 Bulk versus Surface Erosion; 2.6 Degradation Product Cytotoxicity; 2.7 Conclusion; References; 3 Nanomedicine; 3.1 Polyphosphazenes in Immunology; 3.1.1 Vaccine Adjuvants and Delivery Systems; 3.1.2 Polyphosphazene Electrolytes as Immunological Adjuvants; 3.1.3 Structure Activity Relationships; 3.1.4 Safety Considerations; 3.1.5 Immunological Activity.
- 3.1.6 Polyelectrolyte Microsphere Formulations3.1.7 Alternative Delivery Routes; 3.2 Cationic Polyphosphazenes and their Polyplexes; 3.2.1 Gene Delivery; 3.2.2 Gene Silencing; 3.2.3 Charged Polyphosphazenes for Enteral Drug Delivery; 3.3 Controlled Release from Polyphosphazene Matrices; 3.3.1 Polyphosphazene-based Drug Depot Devices; 3.3.2 Covalently Bound Drug Depot Devices; 3.3.3 Cyclomatrix Polyphosphazenes as Drug Depots; 3.4 Micelles and Polymersomes; 3.5 Polymer Therapeutics; 3.5.1 Macromolecular Drug Carriers; 3.5.2 Polyphosphazene Drug Conjugates.
- 3.5.3 Polyphosphazene Carriers for Photodynamic Therapy3.5.4 Enteral Delivery; 3.6 Thermosensitive Poly(organo)phosphazenes; 3.6.1 Thermosensitive Polymers; 3.6.2 Thermosensitive Polyphosphazene Drug Carriers; 3.6.3 Injectable Hydrogels; 3.7 Conclusion; References; 4 Tissue Engineering; 4.1 Introduction to Tissue Engineering; 4.2 Architecture of Polyphosphazene Scaffolds for Tissue Engineering; 4.2.1 Formats; 4.2.1.1 Linear Polyphosphazenes; 4.2.1.2 Crosslinked Polyphosphazenes; 4.2.2 Properties; 4.3 Applications of Polyphosphazene Scaffolds in Tissue Engineering.
- 4.3.1 Bone Tissue Engineering4.3.2 Endothelial Tissue Engineering; 4.3.3 Neural Tissue Engineering; 4.4 Degradation of Polyphosphazenes Developed for Tissue Engineering; 4.5 Conclusion; References; 5 Opportunities and Challenges; 5.1 From Laboratory to Clinic; 5.2 Future Prospects; References; Abbreviations; Index.