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Optogenetics.
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Berlin :
De Gruyter,
2013.
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| Colección: | Dahlem workshop reports.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Hegemann, Peter. | |
| 245 | 1 | 0 | |a Optogenetics. |
| 260 | |a Berlin : |b De Gruyter, |c 2013. | ||
| 300 | |a 1 online resource (240 pages) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
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| 490 | 1 | |a Dahlem Workshop Reports | |
| 505 | 0 | |a List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools. | |
| 505 | 8 | |a 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem. | |
| 505 | 8 | |a 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. | |
| 505 | 8 | |a 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization. | |
| 505 | 8 | |a 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges. | |
| 500 | |a 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons. | ||
| 520 | |a Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and. | ||
| 588 | 0 | |a Print version record. | |
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 650 | 0 | |a Neural transmission. | |
| 650 | 0 | |a Neural networks (Neurobiology) | |
| 650 | 0 | |a Electrooptical devices. | |
| 650 | 0 | |a Physiological optics. | |
| 650 | 6 | |a Transmission nerveuse. | |
| 650 | 6 | |a Réseaux neuronaux (Neurobiologie) | |
| 650 | 6 | |a Dispositifs électro-optiques. | |
| 650 | 6 | |a Optique physiologique. | |
| 650 | 7 | |a Biophysics. |2 bicssc | |
| 650 | 7 | |a Genetics (non-medical) |2 bicssc | |
| 650 | 7 | |a Human biology. |2 bicssc | |
| 650 | 7 | |a Neurosciences. |2 bicssc | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Zoology |x General. |2 bisacsh | |
| 650 | 7 | |a Electrooptical devices |2 fast | |
| 650 | 7 | |a Neural networks (Neurobiology) |2 fast | |
| 650 | 7 | |a Neural transmission |2 fast | |
| 650 | 7 | |a Physiological optics |2 fast | |
| 650 | 7 | |a Nervennetz |2 gnd | |
| 650 | 7 | |a Optogenetik |2 gnd | |
| 700 | 1 | |a Sigrist, Stephan. | |
| 776 | 0 | 8 | |i Print version: |a Hegemann, Peter. |t Optogenetics. |d Berlin : De Gruyter, ©2013 |z 9783110270716 |
| 830 | 0 | |a Dahlem workshop reports. | |
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