Microfluidics, nanotechnology and disease biomarkers for personalized medicine applications /

In recent years, thousands of cancer biomarkers have been discovered and described in scientific literature. The promise of personalized medicine, where diseases such as cancer are accurately diagnosed and treatments tailored specifically for individuals, is becoming a reality. Significant advances...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Shiddiky, Muhammad J. A. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical, [2013]
Colección:New developments in medical research.
Temas:
Microfluidics.
Nanotechnology.
Microfluidique.
TECHNOLOGY & ENGINEERING > Engineering (General)
TECHNOLOGY & ENGINEERING > Reference.
Biochemical markers.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • MICROFLUIDICS, NANOTECHNOLOGY AND DISEASE BIOMARKERS FOR PERSONALIZED MEDICINE APPLICATIONS
  • MICROFLUIDICS, NANOTECHNOLOGY AND DISEASE BIOMARKERS FOR PERSONALIZED MEDICINE APPLICATIONS
  • Library of Congress Cataloging-in-Publication Data
  • CONTENTS
  • PREFACE
  • Chapter 1 BIO-MEMS (MICROFLUIDICS) FOR CTC DETECTION IN CANCER PATIENTS
  • ABSTRACT
  • 1. INTRODUCTION
  • 1.1. Circulating Tumor Cells as Driving Force in Cancer Metastasis
  • 1.2. Clinical Implications of CTCs
  • 2. ADVENT OF MICROFLUIDICS FOR CTC ISOLATION AND DETECTION
  • 2.1. Microfluidic Technologies for Isolation of Circulating Tumor Cells (CTCs) 2.1.1. Immunoaffinity-Based Isolation
  • 2.1.2. Label-Free Separation
  • 2.2. Integrated Technologies
  • 3. APPLICATIONS FOR DIAGNOSIS, MONITORING, AND PROGNOSIS
  • 3.1. Early Detection/Screening
  • 3.2. Monitoring Patients for Treatment Efficacy and Relapse
  • 3.3. Prognosis
  • 4. UNDERSTANDING FUNDAMENTAL BIOLOGY OF CANCER
  • 4.1. Functional CTC Assays for Cancer Biology
  • 4.2. Therapeutic Targeting of CTCs
  • 5. PREDICTIVE BIOMARKERS DISCOVERY AND PERSONALIZED THERAPIES
  • 6. CURRENT CHALLENGES AND FUTURE DIRECTIONS CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Chapter 2 MICROFLUIDIC FLOW FRACTIONATION FOR ISOLATION OF CIRCULATING TUMOR CELLS
  • ABSTRACT
  • 1. INTRODUCTION
  • 2. SINGLE MULTI-ORIFICE FLOW FRACTIONATION (S-MOFF)
  • 2.1. Theory and Mechanism of Separation
  • 2.2. Analysis of Particle Distribution
  • 2.2.1. Microparticles Migration through the Multi-Orifice Microchannel
  • 2.2.2. Visualization and Analysis of Particle Distribution
  • 3. MULTISTAGE MULTI-ORIFICE FLOW FRACTIONATION (MS-MOFF)
  • 3.1. Development of MS-MOFF Device 3.2. Equivalent Circuit Analysis
  • 3.3. Separation Yield of Multi-Stage Channel
  • 4. MULTI-ORIFICE FLOW FRACTIONATION PLUS DIELECTROPHORESIS (MOFF+DEP)
  • 4.1. Development of MOFF+DEP Device
  • 4.2. Continuous Separation of Breast Cancer Cells from Blood Samples
  • 4.2.1. Hydrophoretic Cell Separation
  • 4.2.2. Dielectrophoretic Cell Separation
  • 5. A PARALLEL MULTI-ORIFICE FLOW FRACTIONATION (P-MOFF)
  • 5.1. Development of p-MOFF Device
  • 5.2. Isolation and Enumeration of CTCs from Breast Cancer Patients
  • CONCLUSION REFERENCES
  • Chapter 3 MICRO/NANOSTRUCTURED SUBSTRATES FOR CELL TYPING, ISOLATION AND DISEASE DIAGNOSTICS
  • ABSTRACT
  • 1. INTRODUCTION
  • 2. MECHANICAL AND HYDRODYNAMIC SEPARATION
  • 3. AFFINITY BASED ASSAYS
  • 4. DIELECTROPHORESIS (DEP)
  • 5. MAGNETIC ISOLATION
  • CONCLUSION
  • REFERENCES
  • Chapter 4 MICROFLUIDIC DEVICES FOR THE ANALYSIS OF DRUGS AND THEIR METABOLITES IN BIOLOGICAL FLUIDS
  • ABSTRACT
  • 1. INTRODUCTION
  • LIST OF ABBREVIATIONS
  • 2. POINT-OF-CARE DEVICES
  • 3. MICROFLUIDICS FOR POC DEVICES

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