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EBSCO_ocn857060866 |
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|a 9781628083170
|q (electronic bk.)
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|a (OCoLC)857060866
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|a RC394.H85
|b G85 2013eb
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|a 616.851
|2 23
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|a UAMI
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|a Guillory, Kevin.
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|a Huntington's disease :
|b symptoms, risk factors and prognosis /
|c Kevin Guillory.
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|a Hauppauge, NY :
|b Nova Science Publishers, Inc.,
|c 2013.
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300 |
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|a 1 online resource (ix, 131 pages) :
|b illustrations.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Neurodegenerative diseases - laboratory and clinical research
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|a Includes bibliographical references and index.
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|a HUNTINGTON'S DISEASE ; Library of Congress Cataloging-in-Publication Data ; Contents ; Preface ; Chapter I Huntington's Disease: From Disease Pathogenesisto Clinical Perspectives ; Abstract ; Clinical Features of Huntington's Disease ; Huntingtin's Structure and Post-Translational Modifications ; Htt Function; Molecular Mechanisms of HD Pathogenesis ; Clinical Perspectives in HD ; Conclusion ; Acknowledgments ; Conflict of Interest ; References ; Chapter II The Role of Brain-Derived Neurotrophic Factor (BDNF)in Huntington's Disease: Trophic Support as a Therapeutic Strategy ; Abstract.
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|a Abbreviations 1. Huntington's Disease ; 2. Brain-Derived Neurotrophic Factor (BDNF) ; 2.1. Neurotrophins ; 2.2. Neurotrophin Receptors and their Normal Functions ; 3. Wild-Type versus Mutant Huntingtin and BDNF ; 3.1. Regulation of BDNF Transcription by Huntingtin ; 3.2. Regulation of BDNF Transport by Huntingtin ; 4. Evidence for Reduced Trophic Support in the HD Brain ; 4.1. Reduction in BDNF Expression in HD Genetic Mouse Models ; 4.2. Reduction in BDNF Expression in the Human HD Brain ; 5. Increasing Trophic Support as a Therapeutic Intervention for HD.
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|a 5.1. Direct Up-Regulation of Striatal BDNF Levels 5.2. Up-Regulation of BDNF Levels by Pharmacological Strategies ; 5.3. Up-Regulation of BDNF Levels by Non-Invasive Strategies; 5.4. Future Directions ; Conclusion ; Acknowledgments ; References ; Chapter III The Legal Ramifications ofHuntington's Disease ; Author's Note ; Abstract ; Introduction ; Clinical Issues Relevant to the Law ; HD and Insurance ; Imposition of Involuntary Status ; Guardianship Hearings ; Family Law ; Criminal Law ; Probate ; Compensation ; Conclusion ; References ; Index.
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590 |
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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650 |
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|a Huntington's disease.
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650 |
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|a Brain
|x Diseases.
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650 |
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|a Huntington Disease
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|a Brain Diseases
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|a Chorée de Huntington.
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|a Cerveau
|x Maladies.
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|a HEALTH & FITNESS
|x Diseases
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|2 bisacsh
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|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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|a MEDICAL
|x Diseases.
|2 bisacsh
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|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
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|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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650 |
|
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|a Brain
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|a Huntington's disease
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|a Neurodegenerative diseases--laboratory and clinical research.
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|a ProQuest Ebook Central
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