Lung cancer : a comprehensive overview /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Gately, Kathy (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical, [2013]
Colección:Cancer etiology, diagnosis, and treatments.
Temas:
Lungs > Cancer.
Lung Neoplasms
Poumons > Cancer.
HEALTH & FITNESS > Diseases > Cancer.
MEDICAL > Oncology.
Lungs > Cancer
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • LUNG CANCER: A COMPREHENSIVE OVERVIEW
  • Library of Congress Cataloging-in-Publication Data
  • Contents
  • Preface
  • Chapter I: The Pathology of Lung Cancer
  • Abstract
  • Introduction
  • Common Lung Cancers
  • Adenocarcinoma
  • Squamous Cell Carcinoma
  • Distinction of Adenocarcinoma from Squamous Cell Carcinoma on Biopsy Specimens
  • Small Cell Carcinoma
  • Large Cell Carcinoma
  • Neuroendocrine Tumours
  • Metastases
  • Other Tumours
  • Staging
  • Molecular Analysis
  • Conclusion
  • References
  • Chapter II: Introduction to Lung Cancer, its Epidemiology and Diagnosis
  • Abstract
  • Introduction
  • International Variation in Lung Cancer Prevalence
  • Age and Lung Cancer
  • Host Factors and Lung Cancer Risk from Smoking
  • Gender Differences in Lung Cancer Incidence
  • Race
  • Second-Hand Tobacco Smoke
  • Non-Smoking Related Exposures for Lung Cancer
  • Radon
  • Occupational Exposures
  • Air Pollutants
  • Body Mass Index as a Risk Factor for Lung Cancer
  • Non-Cancer Lung Disease
  • Genetic Factors in Lung Cancer Risk
  • Diagnosis of Lung Cancer
  • Symptomatic Lung Cancer Detection
  • Asymptomatic Disease: Incidental and Screening Detection
  • Diagnosis of Suspected Lung Cancer
  • Diagnosis Based on Imaging Characteristics
  • Diagnostic Strategies
  • Conclusion
  • References
  • Chapter III: The Effect of Smoking Habit Intensity, Occupation and Diet on Lung Cancer Risk in Males
  • Abstract
  • Introduction
  • Risk Factors
  • Tobacco Smoking
  • Occupational Exposure
  • Diet
  • Case Report
  • Methods
  • Results
  • Conclusion
  • References
  • Chapter IV: Lung Cancer: Treatment in Early Stage
  • Abstract
  • Introduction
  • Adjuvant and Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer
  • Evidence for Adjuvant CT
  • Preoperative CT for Early-Stage NSCLC
  • The Role of Adjuvant RT.
  • Future Directions: Targeted Therapies and Genetic Predictive and Prognostic Biomarkers
  • Conclusion
  • References
  • Chapter V: Lung Cancer: Treatment in Advanced Stages
  • Abstract
  • Introduction
  • Treatment of Stage III Non-Small Cell Lung Cancer (NSCLC)
  • Treatment of Metastatic Non-Small Cell Lung Cancer
  • Initial Systemic Therapy for Advanced NSCLC without an EGFR Mutation or the ALK Fusion Oncogene
  • Initial Treatment with Targeted Agents
  • Second Line Therapy
  • Conclusion
  • References
  • Chapter VI: Management of Stage III N2 NSCLC
  • Abstract
  • Introduction
  • Staging
  • Proving N2 Disease
  • Treatment
  • Goals of Neoadjuvant Therapy
  • Current Controversies
  • Conclusion
  • References
  • Chapter VII: Targeted Therapies in Non-Small Cell Lung Cancer
  • Abstract
  • Introduction
  • Targeted Therapy in Lung Cancer
  • EGFR
  • Targeting EGFR
  • VEGF and VEGFR
  • Targeting VEGFR with Bevacizumab
  • Targeting VEGFR with TKIs
  • EML4-ALK
  • Targeting EML4-ALK
  • KRAS
  • Targeting KRAS
  • HER2
  • Targeting HER2
  • B-RAF
  • Targeting B-RAF
  • C-Met
  • Targeting C-Met
  • PI3K
  • Targeting PI3K
  • MEK
  • Targeting MEK
  • PI3K and MEK Co-Targeted Inhibition
  • IGF1R
  • Targeting IGF1R
  • The Future of Targeted Therapy
  • Conclusion
  • References
  • Chapter VIII: Molecular Mechanisms of Cisplatin Resistance in Lung Cancer
  • Abstract
  • Introduction
  • Resistance Mechanisms
  • Epigenetic Regulation and Cisplatin Resistance
  • Novel Strategies for Overcoming Cisplatin Resistance
  • Conclusion
  • References
  • Chapter IX: Inflammation in Lung Carcinogenesis
  • Abstract
  • Introduction
  • Cancer Related Inflammation
  • Lung Cancer and Inflammation
  • Inflammatory Mediators In Lung Cancer
  • Targeting Inflammation as a Therapeutic Option
  • Conclusion
  • References.
  • Chapter X: The Link between Chronic Obstructive Pulmonary Disease and Lung Cancer: Novel Molecular Insights
  • Abstract
  • Introduction
  • Hazardous Effects of Cigarette Smoking
  • Carcinogenic Compounds in the Side-Stream Smoke
  • Chronic Inflammation in COPD and Lung Cancer
  • Genetics of COPD and Lung Cancer
  • Epigenetic Phenomena and Cigarette Smoke
  • Conclusion
  • References
  • Chapter XI: Diagnosis, Treatment and Follow-Up of Neoplastic Pericardial Disease in Lung Cancer
  • Abstract
  • Introduction
  • Diagnosis
  • Treatment
  • Conclusion
  • References
  • Chapter XII: The Role of Claudin Proteins in Lung Tumorigenesis
  • Abstract
  • Introduction
  • Claudin Family Proteins
  • Post-Translational Modifications of Tight Junction Proteins
  • Tight Junction Proteins and Lung Cancer
  • Crosstalk of Claudins and Occludin with Other Signaling Pathways in Lung Cancer
  • Claudins as Therapeutic Targets
  • Conclusion
  • Acknowledgments
  • References
  • Chapter XIII: The Role of the Arachidonic Acid Pathway in NSCLC Development and Progression: Novel Approaches for Therapeutic Intervention
  • Abstract
  • Introduction
  • 1. Arachidonic Acid Metabolism: Generation and Classification of Eicosanoids
  • 2. Altered Expression of Arachidonic Acid Signalling in NSCLC
  • 3. Effect of the Arachidonic Acid Pathway on Tumour Cell Signalling and Proliferation
  • 4. Arachidonic Acid Mediated Regulation of Tumour Cell Death
  • 5. The Role of Arachidonic Acid Signalling in NSCLC Tumour Angiogenesis
  • 6. Regulation of Adhesion, Migration and Invasion of NSCLC by Arachidonic Acid Pathways
  • 7. Modulation of the Immune System in NSCLC by Arachidonic Acid
  • 8. Targeting Arachidonic Acid Pathways Using Pharmacological and Natural Agents
  • Conclusion
  • References
  • Index.

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