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Structural aspects of protein synthesis.
This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attent...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New Jersey :
World Scientific,
©2013.
|
| Edición: | 2nd ed. / |
| Colección: | Series in structural biology.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Liljas, Anders. | |
| 245 | 1 | 0 | |a Structural aspects of protein synthesis. |
| 250 | |a 2nd ed. / |b Anders Liljas, Sweden Måns Ehrenberg. | ||
| 260 | |a New Jersey : |b World Scientific, |c ©2013. | ||
| 300 | |a 1 online resource (xi, 438 pages). | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Series in Structural Biology ; |v v. 1 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Ch. 1. The basics of translation -- ch. 2. Historical milestones -- ch. 3. Methods of studying structure. 3.1. Low-resolution methods. 3.2. High-resolution methods. 3.3. Computational methods -- ch. 4. The message -- mRNA. 4.1. The genetic code. 4.2. Transcription. 4.3. Processing of the transcribed RNA. 4.4. Translational regulation, reading frame and usage of the genetic code -- ch. 5. The adaptor -- tRNA. 5.1. The tRNAs. 5.2. tRNA structures. 5.3. Charging -- the tRNA synthetases. 5.4. Recognition of amino acids and tRNAs by aminoacyl-tRNA synthetases. 5.5. Deviations -- ch. 6. The workbench -- ribosomes. 6.1. The composition of ribosomes. 6.2. rRNA. 6.3. Ribosomal proteins. 6.4. The assembly of ribosomes -- ch. 7. The structure of the ribosome. 7.1. Early studies of the structure of ribosomal subunits and ribosomes. 7.2. Crystal structures of ribosomes. 7.3. The inter-subunit bridges. 7.4. The structures of the ribosomal RNA molecules. 7.5. The structures of ribosomal proteins. 7.6. The structures of eukaryotic and mitochondrial ribosomes -- ch. 8. Ribosomal sites and ribosomal states. 8.1. The binding of mRNA. 8.2. The tRNA binding sites. 8.3. The peptidyl transfer center. 8.4. The polypeptide exit tunnel. 8.5. The GTPase binding site. 8.6. The ribosomal states -- ch. 9. The catalysts -- translation factors. 9.1. The trGTPases. 9.2. Initiation factors. 9.3. Elongation factors. 9.4. Release factors. 9.5. Ribosome-recycling factor. 9.6. tRNA mimicry. 9.7. Ribosome rescue factors/ribosomal protection proteins -- ch. 10. Inhibitors of protein synthesis -- antibiotics, resistance. 10.1. Inhibitors of initiation. 10.2. Inhibitors of aminoacyl-tRNA binding. 10.3. Interference with decoding; distortion of fidelity. 10.4. Inhibitors of peptidyl transfer. 10.5. Inhibitors of the exit tunnel. 10.6. Inhibitors of transslocation. 10.7. Inhibitors of translation factors -- ch. 11. The process -- translation. 11.1. The dynamics of translation and the ribosome. 11.2. Central assays. 11.3. Initiation. 11.4. Elongation. 11.5. Termination. 11.6. Ribosome recycling -- ch. 12. Protein processing, folding and targeting. 12.1. Processing of the nascent peptide. 12.2. Folding of the nascent chain. 12.3. Transport of the nascent polypeptide -- ch. 13. Evolution of the translation apparatus. 13.1. Evolution of the genetic code, tRNAs and tRNA synthetases. 13.2. The evolution of ribosomal RNAs. 13.3. Evolution of proteins in translation. 13.4. The RNA world or RNA-dominated world. | |
| 520 | |a This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation. There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system. | ||
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 650 | 0 | |a Proteins |x Synthesis. | |
| 650 | 6 | |a Protéines |x Synthèse. | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Proteins |x Synthesis. |2 fast |0 (OCoLC)fst01079764 | |
| 700 | 1 | |a Ehrenberg, Måns. | |
| 776 | 0 | 8 | |i Print version: |a Liljas, Anders. |t Structural aspects of protein synthesis. |b 2nd edition. |d New Jersey : World Scientific, [2013] |z 9789814313209 |w (DLC) 2013018180 |w (OCoLC)844789755 |
| 830 | 0 | |a Series in structural biology. | |
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