Cargando…
Estrogen action, selective estrogen receptor modulators, and women's health : progress and promise /
This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the wo...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Imperial College Press,
2013.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- About the Author and Editor; Contributors; Acknowledgements; Forewords Nancy Brinker Bert W. O'Malley; Introduction: The Foundation of a Career V. Craig Jordan; A NEW STRATEGY: LONG-TERM ADJUVANT TAMOXIFEN; REFERENCES; Chapter 1 A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention V. Craig Jordan; BEGINNINGS AT THE DAWN OF THE 20TH CENTURY; LINKS BETWEEN SEX STEROIDS AND CANCER; CONCEPTUAL PROGRESS THROUGH SCIENTIFIC SERENDIPITY; A TARGET FOR TREATMENT AND PREVENTION; AN UNLIKELY THERAPEUTIC SOLUTION
- TARGETING TREATMENT FOR BREAST CANCERCHEMOPREVENTION OF BREAST CANCER; MOLECULAR MECHANISMS OF ESTROGEN AND SERM ACTION; DRUG RESISTANCE TO SERMS; PARALLEL PATH OF THE PROSTATE; THE SUCCESSFUL EVOLUTION OF TARGETED ANTIHORMONAL THERAPY IN THE 20TH CENTURY AND BEYOND; ACKNOWLEDGEMENTS; REFERENCES; Chapter 2 Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment Joan Lewis-Wambi and V. Craig Jordan; INTRODUCTION; THE HISTORY OF DES; Side Effects in Women Prescribed DES During Pregnancy (First Generation)
- Side Effects in DES Daughters and Sons (Second Generation)Side Effects of DES in the Third Generation; MOLECULAR MECHANISMS OF DES ACTION; MECHANISMS OF DES-INDUCED CARCINOGENESIS; ESTROGEN (DES) THERAPY AND PROSTATE CANCER; ESTROGEN (DES) THERAPY AND BREAST CANCER; MECHANISM OF ESTROGEN-INDUCED APOPTOSIS IN BREAST CANCER; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3 Oral Contraceptives and Women's Health V. Daniel Castracane and V. Craig Jordan; INTRODUCTION AND HISTORY; NONCONTRACEPTIVE BENEFITS; ADVERSE EFFECTS; NEW FORMULATIONS OF THE ESTROGEN-PROGESTIN CONTRACEPTIVES
- CONTINUOUS ORAL CONTRACEPTIVESCONTRACEPTION AT MORE THAN 40 YEARS OF AGE; CLOSING THOUGHTS; REFERENCES; Chapter 4 Hormone Replacement Therapy and Women's Health Jennifer Eng-Wong, Ifeyinwa Obiorah and V. Craig Jordan; STRATEGIES IN DISEASE PREVENTION; USAGE OF ESTROGEN REPLACEMENT THERAPY, APPROVALS IN THE UNITED STATES; PREPARATION AND CONTENT OF ERT; RESULTS OF HRT RANDOMIZED TRIALS; HRT and Vascular Disease; HRT and Cancer Risk; Breast Cancer; Gynecologic Cancers; Colon Cancer; Lung Cancer; HRT and Bone Health; HRT and Menopausal Symptoms; HRT and Cognitive Function
- HRT and Gallbladder DiseaseSUMMARY; Challenges of the Future; ACKNOWLEDGEMENTS; REFERENCES; Note Added in Proof; Chapter 5 Induction of Ovulation by Nonsteroidal Antiestrogens Ifeyinwa Obiorah and V. Craig Jordan; INTRODUCTION; EARLY TRIALS WITH CLOMIPHENE CITRATE; CLOMIPHENE RESISTANCE; CURRENT CLOMIPHENE THERAPY AND TREATMENT MONITORING; GESTATIONAL OUTCOME WITH CLOMIPHENE AND SIDE EFFECTS; TAMOXIFEN; TAMOXIFEN AND CLOMIPHENE INDUCTION OF OVULATION; THE USE OF TAMOXIFEN IN OVARIAN STIMULATION IN BREAST CANCER PATIENTS; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES