The placenta : development, function and diseases /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Nicholson, Richard (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical, [2013]
Colección:Pregnancy and infants.
Human reproductive system--anatomy, roles, and disorders series.
Temas:
Placenta.
Placenta > Diseases.
Placenta
Placenta Diseases
Placenta > Maladies.
HEALTH & FITNESS > Pregnancy & Childbirth.
Reproduction
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • THE PLACENTA: DEVELOPMENT, FUNCTION AND DISEASES
  • Library of Congress Cataloging-in-Publication Data
  • Contents
  • Preface
  • Chapter 1: An Overview of Development, Function, and Diseases of the Placenta
  • Abstract
  • Introduction
  • Placental Development
  • Placental Functions
  • Placental Diseases
  • Conclusion
  • References
  • Chapter 2: Emerging Tasks of PAR1 and PAR2 in the Placenta Trophoblast Anchoring to the Uterus Deciduas
  • Abstract
  • Introduction
  • PAR1 Expression in Human Placental Villi
  • PAR1 and b-Catenin Stabilization in a Physiological Invasion Process: The Placenta Trophoblasts
  • Conclusion
  • References
  • Chapter 3: Leptin Action and Leptin Receptor Signaling in Human Trophoblasts
  • Abstract
  • Introduction
  • Leptin Receptor Signaling in Placenta
  • JAK/STAT Signal Transduction Cascade
  • MAPK (Mitogen-Activated Protein Kinase) Cascade
  • The PI3K (Phosphoinositide 3-Kinase) Pathway
  • Sam68 (Src-Associated in Mitosis)
  • Leptin Action in Placenta
  • References
  • Chapter 4: Immunology of Human Pregnancy: Transfer of Antibodies and Associated Placental Function
  • Abstract
  • Introduction
  • The Human Placenta
  • Exploring Methods of Human Placental Function
  • Placental Transport Mechanisms
  • Transport of Immunoglobulin G and Its Subclasses across the Human Placenta
  • Ex Vivo Investigations
  • Immunologic Diseases of Human Pregnancy and Suggested Therapies
  • The Potential of Stem Cells Derived from Human Placenta for Immunotherapy
  • Conclusion
  • References
  • Chapter 5: Effects of Maternal Nutrition Imbalance during Pregnancy on Outcome in Offspring
  • Abstract
  • Introduction
  • Maternal Nutrition Disturbance and Its Adverse Outcome on Offspring Health
  • Placental Transport Activity Associates the Maternal Nutrition Status with the Offspring Outcome.
  • Mechanisms for Maternal Nutrition to Influence Placental Programming of Disease in Offspring
  • Nutritional Interventions for a Better Offspring Outcome
  • Conclusion
  • References
  • Chapter 6: Role of Placental Hypoxia, Oxidative Stress and Alcohol Exposure in Fetal Development
  • Abstract
  • Abbreviations
  • Introduction
  • Embryonic Development
  • Functions of the Placenta
  • Placenta and Oxidative Stress
  • Peroxynitrite Mediates Lipid Oxidation and Nitration
  • Apoptosis in the Placenta
  • Fetal Development and Oxidative Stress
  • Mother´S Alcohol Exposure and Pregnancy Hypertension
  • Hypoxic Stress and Neuroactive Steroid Responses
  • Rat Fetal Alcohol Syndrome and Impaired Placentation
  • Effect of Alcohol on Neural Crest Cells Apoptosis
  • Effect of Alcohol on Embryo Brain Development and Behaviour
  • Effect of Alcohol Exposure on Embryo Cardiac Development
  • Effect of Alcohol Exposure on Embryo Liver Development
  • Conclusion
  • References
  • Chapter 7: The Role of Nitric Oxide in Placental Function
  • Abstract
  • Introduction
  • Oxidative Stress and Nitric Oxide in Normal Pregnancy
  • Preeclampsia: Current Theories
  • Potential Role of L-Arginine
  • A Nitric Oxide Donor
  • In PE Prevention
  • Conclusion
  • References
  • Chapter 8: HCG and Hyperglycosylated HCG, Promoters of Villous Placenta and Hemochorial Placentation
  • Abstract
  • Introduction
  • Methods
  • Results and Discussion
  • References
  • Chapter 9: Exposure to Endocrine Disruptors during Pregnancyand Their Potential HealthEffects on Newborns
  • Abstract
  • Introduction
  • Material and Methods
  • Results
  • Discussion
  • Conclusion
  • References
  • Chapter 10: Placental Transport of Environmental Toxicants
  • Abstract
  • Introduction
  • The Placenta
  • Transport of Substances throughHuman Hemochorial Placenta
  • Human Placental Transfer Models.
  • Placental Transfer of Environmental Toxicants
  • Methods
  • BeWo B30 Clone Monolayer Cell Transfer Model
  • Results
  • Effect of Carrier Molecule Albuminon 14C-Bap Placental Transport
  • Discussion
  • Placental Transport of Halogenated Molecules
  • Causes of Variation in Placental Perfusion Model
  • BeWo Cell Transfer vs. Placental Transfer
  • Conclusion
  • References
  • Chapter 11: Placental Toxicology of Organic Pollutants
  • Abstract
  • 1. Introduction
  • 2. POPs: Characteristics, Sources of Environmental Exposure and Effects
  • 3. Factors Influencing POPs Accumulation in the Placenta
  • 4. Foundations of POPs Toxicity in the Placenta
  • Conclusion
  • Acknowledgments
  • References
  • Chapter 12: The Placental ReninAngiotensin System
  • Abstract
  • Introduction
  • The Renin-Angiotensin System
  • Identification of Placental RAS Gene Expression
  • Expression and Localization ofRAS Proteins in the Placenta
  • Regulation of the Expressionand Activity of the Placental RAS
  • Functions of the Placental RAS
  • The Placental Renin-AngiotensinSystem and Its Role(S) in Preeclampsiaand Intrauterine Growth Restriction
  • Conclusion
  • References
  • Chapter 13: Relationship between Placenta-Preeclampsia and the Long Term Clinical Outcome in Adult Offspring
  • Abstract
  • Introduction
  • Fetal Programing
  • Placental Coagulable State
  • Placental Vascularization
  • High-Altitude Hypoxia and Preeclampsia
  • Placental Transport of Amino Acids
  • Maternal Fetal Nutrition and Adult Life Diseases
  • Polyunsaturated Fatty Acids-Placenta and Maternal Nutrition
  • Conclusion
  • References
  • Chapter 14: Mitochondrial ATP-Diphosphohydrolase and Steroidogenesis in the Human Placenta
  • Abstract
  • Introduction
  • Architecture of Human Placental Mitochondria
  • ATP-Induced Oxygen Uptake by Syncytiotrophoblast Mitochondria.
  • Kinetic Analysis of ATP-Diphosphohydrolase Activity
  • Role of ATP-Diphosphohydrolase in Progesterone Synthesis
  • Syncytiotrophoblast metabolism and the Mitochondria
  • Conclusion
  • Acknowledgment
  • References
  • Chapter 15: Characterization and ClinicalApplication of Mesenchymal StemCells Derived from Placenta
  • Abstract
  • Introduction
  • Isolation and Characterizationof MSC Derived from Placenta
  • Differentiation Potential
  • Applications
  • Conclusion
  • References
  • Chapter 16: The Role of the Primate Placentain Term and Preterm Parturition
  • ABSTRACT
  • INTRODUCTION
  • Conclusion
  • References
  • Index.

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