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Animal models in cancer research and human disease : applications, outcomes and controversies /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Biomedical/Nova Science Publishers, Incorporated,
[2013]
|
| Colección: | Microbiology research advances series.
Animal science, issues, and professions series. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; ANIMAL MODELS IN CANCER RESEARCH AND HUMAN DISEASE ; Contents ; Preface ; Murine Models of Sporadic and Inflammation-Related Colon Carcinogenesis with Particular Focus on the AOM/DSS Chemically Induced Colorectal Cancer Model ; Abstract ; Introduction ; A Variety of CRC Models: Benefits and Limits ; Chemically Induced Colon Carcinogenesis in Rodents ; The AOM/DSS Model in the Study of Colorectal Carcinogenesis ; Histogenesis of Colon Cancer in AOM/DSS Model
- from the Emergence of Precancerous Lesions to Late Carcinomas.
- Molecular Events Associated with Colon Carcinogenesis in the AOM/DSS Model and Relevance for Human CRC Wnt/APC/Ý-Catenin Pathway ; K-Ras ; c-Myc ; TGF-Ý ; Cox-2 ; iNOS ; p53 Pathway ; Epigenetic Modifications ; Pathogenesis and Molecular Biology of Colitis-Induced Carcinogenesis in the AOM/DSS Model; Proinflammatory Factors ; Regulatory Factors ; Chemokines ; Toll Like Receptors ; TIR8 ; Heparanase ; Oxidative Stress and DNA Damage; The AOM/DSS Model in Preclinical Studies ; Natural Plant Compounds ; Modulation of Physiological Molecules ; Synthetic Drugs ; Conclusion ; Acknowledgment.
- 3.3. Mechanical Injury Induced Neointimal Hyperplasia 4. Animal Models of Structural Heart Disease ; 4.1. Ischemic Mitral Regurgitation ; Conclusion ; Acknowledgment ; References ; Canine Breast Cancer and Lymphoma as Modelsin Cancer Research ; Abstract ; 1. Introduction ; 1.1. Dogs as Appropriate Animal Models of Human Cancers ; 2. Canine Mammary Tumor Model ; 2.1. Expression Defects of Cell Cycle Regulators in the CMT Model ; Deregulation of p16/INK4A/ARF/INK4B Locus in CMTs ; 2.2. Genome-Wide Comparative Analysis of the Role of Critical Genes Involved in Human and Canine Mammary Tumors.
- 2.3. Expression of miRNAs in Human Breast Cancer and the CMT Model 3. Canine Lymphoma Model ; Conclusion ; References ; Development of Cell Therapeutic Strategies for Alzheimer's Disease Using Animal Models ; Abstract ; Introduction ; Amyloid Cascade Hypothesis ; Transgenic Mice Models of AD ; Therapeutic Strategies Using Transgenic Mice Models of AD ; Microglia in the AD Brain ; Cell Therapeutic Strategies for AD ; Conclusion ; Acknowledgments ; References ; Animal Models for AntineoplasticChemotherapy-Induced Alopecia; Abstract ; Introduction ; The Biology of the Hair Follicles (HFs)