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Valproic acid : pharmacology, mechanisms of action and clinical implications /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Biomedical,
[2013]
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| Colección: | Pharmacology-research, safety testing, and regulation series.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- VALPROIC ACID ; VALPROIC ACID; Contents ; Preface ; Novel Applications of the Anticonvulsant DrugValproic Acid in Cancer Therapeutics ; Abstract ; Abbreviations and Explanations ; 1. The Involvement of VPA in Cancer and the Associated Signaling Pathways ; 2. VPA Acts as a HDAC Inhibitor; 3. VPA Acts as a Notch Regulator ; 3.1. VPA Acts as a Positive Notch Regulator ; 3.1.1. Neuroendocrine Tumors (NETs) ; 3.1.2. Non-neuroendocrine Tumors (nonNETs) ; 3.2. VPA Acts as a Negative Notch Regulator ; 4. VPA Acts as a GPCR Regulator and Enhances Receptor-TargetedChemotherapeutics.
- 4.1. VPA Acts as a GPCR Regulator 4.1.1. Melatonin MT1 Receptor ; 4.1.2. Chemokine Receptor (CXCR) ; 4.1.3. Somatostatin Receptors (SSTRs) ; 4.1.4. VPA-mediated Other Receptors ; 4.2. VPA Enhances GPCR-targeted Anti-cancer Therapeutics ; 5. The Application of VPA in Combination with Other Anti-cancer Agents ; 5.1. Neuroblastoma ; 5.2. Breast Cancer ; 5.3. Glioblastoma ; 5.4. Glioma ; 5.5. Prostate Cancer ; 5.6. Malignant Pleural Mesothelioma (MPM); 5.7. Colonrectal Cancer ; 5.8. Leukemia and Lymphoma ; 5.8.1. AML ; 5.8.2. ALL ; 5.9. Melanoma ; 5.10. Cervical Cancer.
- 5.11. Renal Cell Cancer (RCC) 5.12. Thyroid Cancer ; 5.13. Carcinoid ; 5.14. Hepatocellular Cancer (HCC) ; 5.15. Myeloma ; 5.16. Esophageal Squamous Cell Cancer (ESCC) ; 5.17. Cholangiocarcinoma ; 5.18. Lung Cancer ; 5.19. Pancreatic Cancer ; Conclusion ; References ; Valproic Acid and Epilepsy:From Basic Research to Clinical Findings ; Abstract ; Introduction ; VPA and Brain Disorders ; Neuropsychiatric Disorders ; VPA and Epilepsy ; Seizures and Epilepsy Definitions ; Basic Study Findings ; Clinical Study Findings ; VPA Mechanisms of Action in Epilepsy ; GABAergic and Glutamatergic System.
- HDAC Inhibitor and Neuropeptide Y Neuroprotective and Antiapoptotic Effects of VPA; VPA and Neurogenesis ; Conclusion ; Disclaimer ; Acknowledgments ; References ; Use of Fish Models in Fetal Valproate Syndrome Study ; Abstract ; Introduction ; Japanese Medaka as a Model to Study Fetal Valproate Syndrome ; Conclusion ; Acknowledgments ; References ; Valproic Acid, Genetics, and Autism: How EpimutationAlters Disease Susceptibility ; Abstract ; Introduction ; DNA Flexibility Promotes Instability ; Autism and Mutation Susceptibility ; Conclusion ; References.
- Determination of Acute Lethal and Chronic Lethal Dose Thresholds of Valproic Acid Using 3D Spheroids Constructed from the Immortal Human Hepatocyte Cell Line HepG2/C3A Abstract ; Introduction; Materials and Methods ; Standard 2D Cell Culture Conditions; 3D Spheroid Culture Conditions Preparation of Spheroids Using AggreWell Plates ; Spheroid Culture in ProtoTissue Bioreactors ; Microscopy and Planimetry ; Drug Treatment ; ATP Assay; Adenylate Kinase Assay for Cell Viability ; Protein Determination ; Glucose Determination ; Results ; Discussion ; Molecular Basis for VPA Toxicity.