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Alzheimer's disease research compendium /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Nova Biomedical,
[2013]
|
| Colección: | Neurodegenerative diseases-laboratory and clinical research
Neuoroscience Research Progress |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- ALZHEIMER'S DISEASE RESEARCH COMPENDIUM; ALZHEIMER'S DISEASE RESEARCH COMPENDIUM; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: SSAO and AÝ in the Vascular Damage of the Temporal Cortex from Alzheimer and Alzheimer with Diabetes Patients; Abstract; Introduction; Experimental Procedures; Human Brain Samples; Immunohistochemistry Technique; Immunopositive Vessels and Neurons Counting; Statistical Analysis; Results; SSAO and AÝ Vessels Immunostaining; SSAO-Positive Vessels and Neuronal Damage; SSAO-Positive Vessels and Glial Activation.
- SSAO-Positive Vessels and Vascular DamageConclusion; Acknowledgments; References; Chapter 2: Amyloid Precursor Protein in Central and Peripheral Cholinergic Synaptopathies; Chapter 2: Amyloid Precursor Protein in Central and Peripheral Cholinergic Synaptopathies; Abstract; Introduction; Functional Role and Metabolism of APP and Derived Fragments; APP Intracellular C-Terminal Domain (AICD); APP Extracellular Domain; Amyloid Peptide; APP and Cholinergic Transmission; APP and Cholinergic Synaptopathies; Conclusion; Acknowledgments; References.
- Chapter 3: In Vivo Analysis Using a Presenilin -1-Specific Inhibitor: Presenilin1-Containing y-Secretase Complexes Mediate the Majority of CNS AB Production in the MouseAbstract; Introduction; Materials and Methods; Synthesis of ZI-10; Cell Free -Secretase Assay; Cell-based Assay for -Secretase Mediated A Production; Animal Handling and Drug Administration; Determination of A 40 Levels in Brain Homogenates and Plasma; Brain and Plasma Drug Exposure Analysis; Brain Slice Uptake Experiment and Sample Preparation; Determination of Fu, plasma by Equilibrium Dialysis Experiment; Results.
- ZI-10 Inhibits A 40 Production in a Cell-free Assay for -Secretase ActivityZI-10 Inhibits A Production in Cultured Cells; ZI-10 Preferentially Inhibits PS1-Mediated A 40 Production; ZI-10 Reduces A 40 Levels in the Mouse Brain but not in the Plasma; Discussion; Acknowledgments; References; Chapter 4: Insight into 'Synaptopathy' in Alzheimer's Disease: From Lifestyle to PS1/N-Cadherin Interaction; Abstract; Introduction; 1) Evidence for 'Synaptopathy' in AD; 2) Implications of Diverse Lifestyles for AD; 3) Molecular Mechanisms of 'Synaptopathy' in AD: Potential Roles of PS1.
- 4) Towards Synapse-targeting Approaches for Prevention and Therapeutics of ADReferences; Chapter 5: Interaction and Stimulation through a Computer: A Program Specially Designed for Mild to Moderate Alzheimer's Patients; Abstract; Introduction; Methodology; Program Concept; 1) Web Conferencing: (Figure 2); 2) Help with Taking Medications; 3) Cognitive Stimulation Program (Figures 3 to 5); Goals; Subjects; Procedure; Outcome Measures; 1) Pre-defined Clinical Questionnaire to Evaluate; 2) Mood; Results; I.1. a) Patients' Social-professional Status and Performance Speed (See Table 1)