Bioactive heterocycles : synthesis and biological evaluation /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Ameta, K. L. (Editor ), Pawar, R. P. (Editor ), Domb, A. J. (Abraham J.) (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York : Nova Biomedical, [2013]
Colección:Biochemistry research trends series.
Temas:
Heterocyclic compounds > Synthesis.
Bioactive compounds > Synthesis.
Composés hétérocycliques > Synthèse.
Composés bioactifs > Synthèse.
SCIENCE > Chemistry > Organic.
Heterocyclic compounds > Synthesis
Acceso en línea:Texto completo
Tabla de Contenidos:
  • BIOACTIVE HETEROCYCLES: SYNTHESIS AND BIOLOGICAL EVALUATION; BIOACTIVE HETEROCYCLES: SYNTHESIS AND BIOLOGICAL EVALUATION; Library of Congress Cataloging-in-Publication Data; Contents; Preface; About the Editors; Contributors; Chapter 1: Multipotent 1,8-Naphthyridines, as New Tacrine Analogues, for the Treatment of Alzheimer's Disease; Abstract; 1. Introduction; 2. 4H-Pyrano [2,3-b]Pyridines (Pyranotacrines); 2.1. Synthesis; 2.2. Pharmacology; 3. Furo and Thieno[2,3-b]pyridines (Furo and Thienotacrines); 3.1. Synthesis; 4. 4-Aryl-1,8-naphthyrydines (Pyridotacrines); 4.1. Synthesis.
  • 4.2. PharmacologyConclusion; References; Chapter 2: Pyrrolo [1,2-a] Quinolines: Synthesis and Biological Activity; Abstract; 1. Introduction; 2. Synthetic Routes to Pyrrolo[1,2-a]Quinolines; 2.1. Synthesis Starting from Quinoline and Its Derivatives; 2.2. Synthesis Starting from Pyrroles; 2.3. Other Methods for Obtaining Pyrrolo[1,2-a]Quinolines; 2.4. Bioactive Compounds Based on Pyrrolo[1,2-a]Quinolines; Conclusion; Acknowledgments; References; Chapter 3: Aziridines: Synthesis and Bioactivity; Abstract; 1. Introduction; 2. Overview and General Features; 3. Synthesis of Aziridines.
  • 3.1. From Addition to Alkenes3.2. From Ü, Ý-Unsaturated Carbonyl Compounds; 3.3. From Imines; 3.4. From Ring Closure of Haloamines and Amino Alcohols; 3.5. By Ring Transformation of Epoxides; 3.6. Miscellaneous Synthesis; 4. Biological Activity of Aziridines; 4.1. Cytotoxic and Anticancer Activities; 4.2. Antimicrobial Activities; 4.3. Protein Inhibitor Aziridines; 4.4. Antibiotic and Miscellaneous Activities of Aziridines; Conclusion; References; Chapter 4: Bioactivity and Synthesis of Substituted Imidazole Motifs; Abstract; 1. Introduction.
  • 2. Biological Importance of Substituted Imidazole Derivatives2.1. Cyclooxygenase-2 (COX-2) Inhibitors Activity of imidazoles; 2.2. Inhibitors of p38 MAP Kinase Activity of imidazoles; 2.3. Combretastatin A-4 (CA-4) Analogues with Antitumor Activity; 2.4. Modulators of P-glycoprotein (P-gp)-mediatedMultidrug Resistance (MDR); 2.5. GSK3 Inhibitors Activities for Substituted imidazoles; 2.6. Anti-inflammatory Activity for Substituted imidazole Derivatives; 2.7. Antimicrobial Activity of Substituted imidazoles i.e. Antibacterial & Antifungal Activity.
  • 2.8. Other Biological Activity of Substituted imidazoles3. Methods of Synthesisfor Substituted Imidazoles; Conclusion; References; Chapter 5: Synthesis and Biological Activity of Five-, Six- and Seven-membered S, N-Containing Saturated Heterocycles; Abstract; 1. Introduction; 2. Discussion; 2.1. One-pot Cyclothiomethylation Reaction; 2.2. Biological Activity; Conclusion; References; Chapter 6: Synthesis and Bioactivity of Dihydropyrimidines; Abstract; 1. Introduction; 2. Biological Activities of DHPMs; 2.1. Antifungal Activity; 2.2. Antibacterial Activity; 2.3. Anti-inflammatory Activity.

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