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Chemogenomics : knowledge-based approaches to drug discovery /
In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, "Chemogenomics" aims to iden...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London : Hackensack, NJ :
Imperial College Press ; Distributed by World Scientific Pub.,
©2006.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Chemogenomics : |b knowledge-based approaches to drug discovery / |c editor, Edgar Jacoby. |
| 260 | |a London : |b Imperial College Press ; |a Hackensack, NJ : |b Distributed by World Scientific Pub., |c ©2006. | ||
| 300 | |a 1 online resource (ix, 209 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, "Chemogenomics" aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays. This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided | ||
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
| 538 | |a Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. |u http://purl.oclc.org/DLF/benchrepro0212 |5 MiAaHDL | ||
| 583 | 1 | |a digitized |c 2010 |h HathiTrust Digital Library |l committed to preserve |2 pda |5 MiAaHDL | |
| 505 | 0 | |a Ch. 1. Small molecules for chemogenomics-based drug discovery / Edgar Jacoby ... [et al.] -- ch. 2. Mapping the chemogenomic space / Jordi Mestres -- ch. 3. Natural product scaffolds and Protein Structure Similarity Clustering (PSSC) as inspiration sources for compound library design in chemogenomics and drug development / Frank J. Dekker, Stefan Wetzel and Herbert Waldmann -- ch. 4. A reductionist approach to chemogenomics in the design of drug molecules and focused libraries / Roger Crossley and Martin Slater -- ch. 5. In silico screening of the protein structure repertoire and of protein families / Didier Rognan -- ch. 6. New methods for similarity-based virtual screening / Jérôme Hert, Peter Willett and David J. Wilton -- ch. 7. Structural informatics: chemogenomics in silico / Derek A. Debe, Kevin P. Hambly and Joseph F. Danzer -- ch. 8. Construction of a homogeneous and informative in vitro profiling database for anticipating the clinical effects of drugs / Nicolas Froloff ... [et al.]. | |
| 590 | |a eBooks on EBSCOhost |b EBSCO eBook Subscription Academic Collection - Worldwide | ||
| 650 | 0 | |a Chemogenomics. | |
| 650 | 0 | |a Pharmacogenetics. | |
| 650 | 0 | |a Drugs |x Design. | |
| 650 | 0 | |a Genomics. | |
| 650 | 2 | |a Pharmacogenetics | |
| 650 | 2 | |a Combinatorial Chemistry Techniques | |
| 650 | 2 | |a Drug Design | |
| 650 | 2 | |a Genomics | |
| 650 | 6 | |a Chémogénomique. | |
| 650 | 6 | |a Pharmacogénétique. | |
| 650 | 6 | |a Médicaments |x Conception. | |
| 650 | 6 | |a Génomique. | |
| 650 | 7 | |a MEDICAL |x Drug Guides. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Nursing |x Pharmacology. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Pharmacology. |2 bisacsh | |
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| 650 | 7 | |a Pharmacogenetics |2 fast | |
| 650 | 7 | |a Genomics |2 fast | |
| 650 | 7 | |a Drugs |x Design |2 fast | |
| 650 | 7 | |a Chemogenomics |2 fast | |
| 650 | 7 | |a Chémogénomique. |2 ram | |
| 650 | 7 | |a Génomique. |2 ram | |
| 650 | 7 | |a Chimie combinatoire. |2 ram | |
| 700 | 1 | |a Jacoby, Edgar. | |
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