Recent advances in psoriasis : the role of the immune system /

This book presents the evidence for the belief that psoriasis is a disease of abnormal keratinocyte proliferation induced by T cells. The latest approaches to investigating the immunopathogenesis of this disease, and a review of previous findings, are presented to give an overall picture of the curr...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Baker, Barbara S.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : River Edge, N.J. : Imperial College Press ; Distributed by World Scientific Pub. Co., ©2000.
Temas:
Psoriasis.
Immune system.
Psoriasis
Immune System
Immune System Phenomena
Système immunitaire.
MEDICAL > Dermatology.
Immune system
Autoimmunität
Schuppenflechte
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Ch. 1. Aetiology, clinical and histological features of psoriasis. 1.1. Clinical features
  • 1.2. Genetics
  • 1.3. Environmental factors
  • 1.4. Histological features
  • ch. 2. Skin immune system in psoriasis. 2.1. Skin immune system (SIS)
  • 2.2. T cell subpopulations: normal skin
  • 2.3. T cell subpopulations: psoriatic skin
  • 2.4. Antigen-presenting cells: normal skin
  • 2.5. Antigen-presenting cells: psoriatic skin
  • 2.6. Endothelial cells
  • 2.7. Neutrophils
  • 2.8. Mast cells
  • 2.9. Keratinocytes
  • ch. 3. Immune cell function in psoriasis. 3.1. T lymphocytes: peripheral blood
  • 3.2. T lymphocytes: skin
  • 3.3. Antigen-presenting cells
  • ch. 4. Psoriasis is a T cell-mediated disease. 4.1. Anti-psoriatic treatments
  • 4.2. Anti-CD4 monoclonal antibodies
  • 4.3. Lymphocyte-selective toxin (DAB[symbol]IL-2)
  • 4.4. SCID mouse models
  • 4.5. Bone-marrow transplantation
  • 4.6. T cell supernatants promote keratinocyte proliferation
  • 4.7. Low CD4[symbol]/HIV infection
  • ch. 5. ß haemolytic streptococci and psoriasis. 5.1. Group A streptococci as a trigger for guttate psoriasis
  • 5.2. Group A streptococci and CP psoriasis
  • 5.3. Induction of psoriatic lesions by streptococci
  • 5.4. Streptococcal antigens
  • 5.5. Immune response to extracellular streptococcal proteins and superantigens
  • 5.6. Immune response to streptococcal cellular proteins
  • ch. 6. Immune function of psoriatic keratinocytes. 6.1. Cytokine production
  • 6.2. Response to cytokines
  • 6.3. Antigen/superantigen presentation
  • 6.4. Integrins
  • 6.5. Apoptosis
  • ch. 7. Current and future immunological approaches to treatment of psoriasis. 7.1. Current treatments
  • 7.2. Future treatments
  • ch. 8. Model for the immunopathogenesis of psoriasis. 8.1. Outline of proposed model
  • 8.2. Antigen trigger: group A streptococci (GAS)
  • 8.3. CD4[symbol] T lymphocyte/KC interaction
  • 8.4. Role of CD8[symbol] T lymphocytes
  • 8.5. Site of altered gene expression
  • 8.6. Other antigenic triggers.

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