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Methodologies for metabolomics : experimental strategies and techniques /

"While most of the focus in "omics" science over the past decade has been on sequencing the human genome [1] or annotating the human proteome [2], there is another equally important component of the human body that has, until recently, been largely overlooked: the human metabolome. Th...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Lutz, Norbert W. (Norbert Winfried), 1952-, Sweedler, Jonathan V., Wevers, Ron A. (Ronald Allan), 1951-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge ; New York, NY : Cambridge University Press, 2013.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Section 1: Basic Methodological Strategies in Metabolomic Research
  • Exploring the Human Metabolome by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry
  • Methodological Requirements for Lipidomics Research
  • Biological Methods for Metabolic Research
  • Section 2: Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics
  • Considerations in Sample Preparation, Collection, and Extraction Approaches Applied in Microbial, Plant, and Mammalian Metabolic Profiling
  • Mass Spectrometry-Based Methodologies for Single-Cell Metabolite Detection and Identification
  • Direct Metabolomics from Tissues and Cells: Laser Ablation Electrospray Ionization for Small Molecule and Lipid Characterization
  • Bioinformatic Approaches to Processing and Annotation of High-Resolution Mass Spectrometry Data
  • Approaches for Natural Product Detection and Structural Elucidation Using Mass Spectrometry with High Mass Accuracy
  • Metabolomics Using Ion Mobility Mass Spectrometry
  • Metabolmics via Biomedical Mass Spectrometry: From Sampling to Clinical Applications
  • Section 3: Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics
  • Analytical Techniques in Metabolomics Integrating Nuclear Magnetic Resonance Spectroscopy and Chromatography with Mass Spectrometry
  • Chemometric Methods in Nuclear Magnetic Resonance-Based Body Fluid Analysis
  • Nuclear Magnetic Resonance of Cerebrospinal Fluid: The Neurometabolome
  • Nuclear Magnetic Resonance-Based Saliva Metabolomics
  • Nuclear Magnetic Resonance Methods for Metabolomic Investigation of Amniotic Fluid
  • Nuclear Magnetic Resonance Analysis and Genetic Metabolic Disease
  • Lipid Profiling in Health and Disease
  • Section 4: Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis
  • Magnetic Resonance Spectroscopy in Investigating the Cancer Metabolome in Preclinical Model Systems
  • Phospholipidomics by Phosphorus Nuclear Magnetic Reasonance Spectroscopy of Tissue Extracts
  • Carbon-13 Nuclear Magnetic Resonance for Analysis of Metabolic Pathways
  • Hyperpolarized Nuclear Magnetic Resonance Spectroscopy: A New Method for Metabolomic Research
  • Metabolomic Magnetic Reasonance Spectroscopy of Human Tissues: Comparison of In Vivo and High-Resolution Magic Angle Spinning Ex Vivo Techniques
  • Reproducible Sample Preparation and Spectrum Acquisition Techniques for Metabolic Profiling of Human Tissues by Proton High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance
  • Assignment Strategies for Nuclear Magnetic Resonances in Metabolomic Research