Silica nanoparticles as drug delivery system for immunomodulator GMDP /

The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging i...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Parfenyuk, E. V.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, N.Y. : [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : ASME ; Momentum Press, 2012.
Colección:Biomedical & nanomedical technologies.
Temas:
Drug delivery systems.
Nanosilicon.
Immunological adjuvants.
Nanomedicine.
Nanoparticles.
Endometriosis > Treatment.
Nanotechnology.
Silicon.
Adjuvants, Immunologic
Drug Delivery Systems
Endometriosis > therapy
Nanomedicine
Nanoparticles
Silicon
Systèmes d'administration de médicaments.
Nanosilicium.
Adjuvants immunologiques.
Nanoparticules.
Endométriose > Traitement.
Nanomédecine.
Silicium.
silicon.
MEDICAL > Pharmacology.
Mesoporous silica
nanoparticles
sol-gel synthesis
surface functionalization
glucosaminyl muramyldipeptide
endometriosis
drug delivery system
drug immobilization
blood lymphocytes
peritoneal macrophages
scavenger receptors
functional activity of the immune cells
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Introduction.
  • 1. Drug delivery nanosystems as a promising area of modern chemistry and medicine. Silica nanoparticles as potential drug carriers.
  • 2. Syntheses of mesoporous silica materials
  • 2.1 Syntheses of unmodified silica materials
  • 2.2 Synthesis of modified silica materials.
  • 3. Characterization of silica materials as potential carriers for GMDP.
  • 3.1 Characterization of silica materials via FTIR spectroscopy
  • 3.2 Characterization of silica materials via nitrogen adsorption-desorption measurements
  • 3.3 Particle size of silica materials
  • 3.4 Characterization of silica materials via small angle x-ray scattering (SAXS)
  • 3.5 Adsorption properties of silica materials
  • 3.6 DSC study of composites of model protein with silica materials
  • 3.7 Calorimetric study of adsorption of model protein on silica materials
  • 3.8 Preparation of silica nanoparticle suspensions.
  • 4. Interaction of silica nanoparticles with immune system cells
  • 4.1 Intensity of different silica nanoparticles uptake by immune cells
  • 4.2 Influence of silica nanoparticles on parameters of functional activity of peritoneal macrophages.
  • 5. Peritoneal macrophages of women with endometriosis as a possible target for immunomodulatory drugs
  • 5.1 Impairment of peritoneal macrophage function at endometriosis
  • 5.2 Influence of glucosaminyl muramyldipeptide upon functional activity of peritoneal macrophages of women with endometriosis.
  • 6. Effectiveness of different types of silica nanoparticles as drug carriers for topical delivery of GMDP into peritoneal macrophages of women with endometriosis
  • 6.1 Immobilization of GMDP on silica nanoparticles
  • 6.2 Comparative study of the effects of free GMDP and GMD immobilized on silica nanoparticles on the functional state of peritoneal macrophages.
  • References.

Ejemplares similares