Silica nanoparticles as drug delivery system for immunomodulator GMDP /

The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging i...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Parfenyuk, E. V.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, N.Y. : [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : ASME ; Momentum Press, 2012.
Colección:Biomedical & nanomedical technologies.
Temas:
Drug delivery systems.
Nanosilicon.
Immunological adjuvants.
Nanomedicine.
Nanoparticles.
Endometriosis > Treatment.
Nanotechnology.
Silicon.
Adjuvants, Immunologic
Drug Delivery Systems
Endometriosis > therapy
Nanomedicine
Nanoparticles
Silicon
Systèmes d'administration de médicaments.
Nanosilicium.
Adjuvants immunologiques.
Nanoparticules.
Endométriose > Traitement.
Nanomédecine.
Silicium.
silicon.
MEDICAL > Pharmacology.
Mesoporous silica
nanoparticles
sol-gel synthesis
surface functionalization
glucosaminyl muramyldipeptide
endometriosis
drug delivery system
drug immobilization
blood lymphocytes
peritoneal macrophages
scavenger receptors
functional activity of the immune cells
Acceso en línea:Texto completo
Descripción
Sumario:The development of nanosystems for topical drug delivery to target cells is a promising tool to improve the drug therapeutic index. Transport systems can be designed to control the dispatch of the loaded drug to target areas, increasing its local concentration and bioavailability, while prolonging its retention, half-life and effectiveness. Therefore, such "smart" nanodevices are able to change radically the practice of therapy for a variety of diseases and disorders. The purpose of this book is to present the recent research development of nanoparticulate delivery systems for immune modulating agent, glucosaminyl muramyldipeptides (N-acetylglucosaminyl-Nacetylmuramyl- L-alanyl-D-isoglutamine) or GMDP, which is the main component of bacterial wall with known target of action through NOD2 receptors, with an overlook to their applications for treatment of endometriosis, which often results in infertility. Silica-based nanoparticles have generated a significant amount of interest because of their inherent properties.
Notas:Title from PDF title page (viewed on September 27, 2012).
Descripción Física:1 online resource (x, 69 pages) : illustrations, digital file
Bibliografía:Includes bibliographical references (pages 59-69).
ISBN:9781606503959
1606503952
1606504215
9781606504215

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