Nanoparticles and brain tumor treatment /

Despite progresses in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limit...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Caruso, Gerardo
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, N.Y. : [New York, N.Y.] (222 East 46th Street, New York, NY 10017) : ASME ; Momentum Press, 2012.
Colección:Biomedical & nanomedical technologies.
Temas:
Nanomedicine.
Nanoparticles.
Brain > Tumors > Treatment.
Nanotechnology.
Brain Neoplasms > therapy
Nanomedicine
Nanoparticles
Nanoparticules.
Cerveau > Tumeurs > Traitement.
Nanomédecine.
MEDICAL > Instruments & Supplies.
Nanotechnology
Nanoparticles in Brain Tumor Treatment
Nanoparticle Drug Delivery
Nanoparticle Targeting
Blood-Brain Barrier
Glioma
Astrocytoma
Glioblastoma
Brain Tumor
Glioma Treatment
Brain Tumor Drug Targeting
Angiogenesis
Polymeric
Nanoparticles and Brain Tumors
Carbon Nanotubes and Brain Tumors
Fullerenes and Brain Tumors
Silica Nanoparticles and Brain Tumors
Micelle Nanoparticles and Brain Tumors
Liposome and Brain Tumors
Acceso en línea:Texto completo
Tabla de Contenidos:
  • 1. Introduction.
  • 2. Glioma biology
  • 2.1 Invasion and angiogenesis.
  • 3. Blood-brain barrier
  • 3.1 Blood-brain barrier physiology
  • 3.2 Blood-brain barrier transport systems.
  • 4. Nanomedicine and nanotechnology
  • 4.1 Nanoparticle drug delivery
  • 4.1.1 Nanoparticle distribution
  • 4.1.2 Nanoparticle functionalization
  • 4.1.3 Nanoparticle targeting
  • 4.2 Nanomedicine and cancer
  • 4.3 Nanomedicine and toxicity.
  • 5. Nanoparticle technologies
  • 5.1 Polymeric and polymer-drug conjugate nanoparticles
  • 5.2 Micelle nanoparticles
  • 5.3 Liposomes
  • 5.4 Gold and silver nanoparticles
  • 5.5 Metal oxide
  • 5.6 Magnetic nanoparticles
  • 5.7 Carbon nanotubes
  • 5.8 Fullerenes
  • 5.9 Peptides nanoparticles
  • 5.10 Silica nanoparticles
  • 5.11 Quantum dots
  • 5.12 Dendrimers.
  • 6. Nanomedicine applications in brain tumors
  • 6.1 Brain tumor drug targeting
  • 6.1.1 Systemic approaches
  • 6.1.2 Physiological approaches
  • 6.1.2.1 Receptor-mediated transcytosis
  • 6.1.2.2 Adsorptive-mediated transcytosis
  • 6.1.2.3 Efflux pump inhibition
  • 6.1.2.4 Cell-mediated drug transport
  • 6.1.3 Direct CNS approaches
  • 6.1.3.1 Intracerebral routes
  • 6.1.4 Drug modifications and prodrugs.
  • 7. Experimental studies.
  • 8. Conclusions
  • References.

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