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The Malaria Genome Projects : Promise, Progress, and Prospects /
The year 2012 marks the tenth anniversary of the announcement of the genome sequence of the human malaria parasite Plasmodium falciparum and that of its mosquito vector Anopheles. The genome sequences were a result of the Plasmodium falciparum Genome Project. This book covers in detail the biology o...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London, UK : Singapore :
Imperial College Press ; Dist. by World Scientific,
Ã2012.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Ch. 1. Introduction. Plasmodium discovered. Plasmodium transmitted. Plasmodium in hiding
- ch. 2. Respice: before the genome project
- ch. 3. The nature of Plasmodium falciparum and its genome. A home for the genome. Location, location, location. The malaria genome capers
- ch. 4. Chipping away at the genome. Turning "on", turning "off". Evasion
- ch. 5. The importance of import
- ch. 6. Remodeling the genome's home
- ch. 7. Getting on the inside
- ch. 8. The great escape
- ch. 9. The neglected malaria, Plasmodium vivax. Resistance. Secrets hidden in the genome
- ch. 10. The Anopheles genome and transmission control. Making mosquitoes immune. Making mosquitoes insecticide resistant. Replacement and/or reduction
- ch. 11. The monkey's tale
- ch. 12. A not so sweet solution. Isoenzymes, the Achilles' heels of Plasmodium. Tackling the Krebs "cycle"
- ch. 13. To search and find. Rapid diagnostic tests. Nucleic acid-based tests. Loop-mediated isothermal amplification
- ch. 14. The elusive vaccines. Antigens before the genome. Two blood-stage vaccine candidates. The road to merozoite surface protein. The road to apical membrane antigen 1. A failed promise, SPf66. Transmission-blocking vaccines. The sporozoite vaccine revisited. Development of the pre-blood-stage vaccine, RTS, S. Back to the future. Learning from the liver. Vaccine approaches before sequencing the genome. Vaccine approaches after sequencing the genome
- ch. 15. New medicines, old problems. The old problem of resistance. Chloroquine. Resistance to anti-folate drugs. Mefloquine and multidrug resistance. The fall of mefloquine. Atovaquone. Artemisia to artemisinins
- ch. 16. Prospice: looking to the future.