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Antibody drug discovery /
Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Imperial College Press,
2012.
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| Colección: | Molecular medicine and medicinal chemistry ;
v. 4. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Ch. 1. Humanization of antibodies / Olivier Leger and Jose W. Saldanha
- ch. 2. Selection and screening of antibody phage display libraries / David R. Buckler [and others]
- ch. 3. Affinity maturation approaches for antibody lead optimization / David Lowe, Trevor Wilkinson and Tristan J. Vaughan
- ch. 4. Transgenic mice rearranging human antibodies / Sean Stevens
- ch. 5. Isotype selection and Fc engineering: design and construction of fit-for-purpose therapeutic antibodies / William R. Strohl
- ch. 6. Antibody expression from bacteria to transgenic animals / Paul Stephens and Berni M. Sweeney
- ch. 7. Current trends in antibody purification and lead selection / Jie Chen and Andrew Nixon
- ch. 8. Design and application of immunoconjugates for cancer therapy / Sherif El Sheikh [and others]
- ch. 9. Dual-targeting bispecific antibodies as new therapeutic modalities for cancer / Zhenping Zhu
- ch. 10. Antibody fragments and alternate protein scaffolds / Lioudmila Tchistiakova [and others].