Cargando…
Recent advances in prostate cancer : basic science discoveries and clinical advances /
This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical prac...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Singapore :
World Scientific Publishing,
2011.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Contributors; Preface; Chapter 1 Pathology of Prostate Lawrence True and Funda Vakar-Lopez; Introduction; Prostate Anatomy; Prostate "Capsule"; Zones of the Prostate; Cell Types of the Prostate; Benign Prostatic Hypertrophy (BPH); Inflammation; Granulomatous Prostatitis; Chronic Prostatitis; Pre-Neoplastic Lesions; Prostatic Intraepithelial Neoplasia (PIN); Other Candidate Pre-Neoplastic Lesions; Prostate Carcinoma; Diagnosis of Prostate Cancer; Differential Diagnostic Considerations; Grading Prostate Carcinoma; Tertiary Gleason pattern; Percentage of Gleason patterns.
- Grade progressionSpindle Cell Lesions; Non-Prostate Spindle Cell Lesions; Prostate Spindle Cell Lesions; Sarcoma of Prostate; Carcinosarcoma (Sarcomatoid Carcinoma) of Prostate; Pathology of Non-Surgical Therapy; Radiation Therapy; Androgen Deprivation (Blockade) Therapy; Neoadjuvant Therapy; Recommendations for Pathology Reports; Needle Biopsy Reports; Radical Prostatectomy Reports; Surgical margin; Extraprostatic extension; Lymph node dissection; Tissue Biomarkers; Future Trends; References; Chapter 2 Genetic Basis for Prostate Cancer Stacy Loeb and William B. Isaacs; Introduction.
- Family-Based StudiesGenome-Wide Association Studies; Future Directions; Conclusions; References; Chapter 3 Androgen Receptor Converts from a Growth Suppressor in the Normal Prostate to an Oncogene in Prostate Cancer Donald J. Vander Griend and John T. Isaacs; Introduction; Androgen Receptor Suppresses the Growth of Normal Prostate Epithelial Cells; Androgen Receptor Functions as an Oncogene in Prostate Cancer; Clinical Implications of AR Conversion from a Growth Suppressor to an Oncogene; Loss of AR-Mediated Growth Suppression Without Gaining Oncogenic Ability; Acknowledgments; References.
- Chapter 4 Etiology: Role of ETS Factor Gene Fusions Jianghua Wang and Michael IttmannIntroduction; ETS Transcription Factor Gene Fusions in Prostate Cancer; Structure and Transcription of the TMPRSS2/ERG Fusion Gene; Origin of the TMPRSS2/ERG Fusion Gene; Alternative Splicing of the TMPRSS2/ERG Fusion Transcript; Pathological Correlations; The ETS Transcription Factor Gene Family; Biological Activities of the ERG and T/E Fusion Gene Protein; Association of T/E Fusion Gene Expression with Global Gene Expression and Copy Number Alterations in Prostate Cancer.
- Genetics of TMPRSS2/ERG Prostate CancerClinical Implications of the TMPRSS2/ERG Fusion Gene; Summary; References; Chapter 5 Etiology of Prostate Cancer: Role of Inflammation William G. Nelson, Angelo M. DeMarzo and Srinivasan Yegnasubramanian; Introduction; Inflammation in the Human Prostate and Prostate Cancer; Sex Steroid Hormones and Inflammation in the Prostate; Infections and Inflammation in the Prostate; Inflammation and Inherited Susceptibility to Prostate Cancer; The Diet and Inflammation in the Prostate; Inflammation and the Molecular Pathogenesis of Prostate Cancer.